Lipopolysaccharide induces prostaglandin H synthase-2 in alveolar macrophages

M. G. O'Sullivan, E. M. Huggins, E. A. Meade, D. L. DeWitt, C. E. McCall

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130 Scopus citations


Prostaglandin H synthase is a key enzyme in the formation of prostaglandins and thromboxane from arachidonic acid. The recent cloning of a second prostaglandin H synthase gene, prostaglandin H synthase-2, which is distinct from the classic prostaglandin H synthase-1 gene, may dramatically alter our concept of how cells regulate prostanoid formation. We have recently shown that the enhanced production of prostanoids by lipopolysaccharide-primed alveolar macrophages involves the induction of a novel prostaglandin H synthase (J. Biol. Chem., (1992), 267, 14547-14550). We report here that the novel PGH synthase induced by lipopolysaccharide in alveolar macrophages is prostaglandin H synthase-2.

Original languageEnglish (US)
Pages (from-to)1123-1127
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - Sep 16 1992

Bibliographical note

Funding Information:
Acknowledgments This work was supported by National and by the American Lung Association.


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