TY - JOUR
T1 - Lipoprotein lipase and hepatic lipase
T2 - Their relationship with HDL subspecies Lp(A-I) and Lp(A-I,A-II)
AU - Cheung, Marian C.
AU - Sibley, Shalamar D.
AU - Palmer, Jerry P.
AU - Oram, John F.
AU - Brunzell, John D.
PY - 2003/8
Y1 - 2003/8
N2 - HDL subspecies Lp(A-I) and Lp(A-I,A-II) have different anti-atherogenic potentials. To determine the role of lipoprotein lipase (LPL) and hepatic lipase (HL) in regulating these particles, we measured these enzyme activities in 28 healthy subjects with well-controlled Type 1 diabetes, and studied their relationship with Lp(A-I) and Lp(A-I,A-II). LPL was positively correlated with the apolipoprotein A-I (apoA-I), cholesterol, and phospholipid mass in total Lp(A-I), and with the apoA-I in large Lp(A-I) (r ≥ 0.58, P ≥ 0.001). HL was negatively correlated with all the above Lp(A-I) parameters plus Lp(A-I) triglyceride (r ≥ -0.53, P ≤ 0.003). No correlation was detected between LPL and Lp(A-I,A-II). However, HL was inversely correlated with total Lp(A-I,A-II) phospholipid, and with large Lp(A-I,A-II) (r ≥ 0.50, P ≤ 0.006). Similar studies were performed with phospholipid transfer protein (PLTP). Only total Lp(A-I) triglyceride in women (not men) (r = 0.71, P = 0.009) was significantly correlated with PLTP activity. These observations indicate that LPL and HL play major roles in determining the level and composition of plasma Lp(A-I), particularly large Lp(A-I), but not with Lp (A-I,A-II) level. Furthermore, select correlations of LPL and/or HL with the apoA-I, cholesterol, and triglyceride of Lp(A-I) but not Lp(A-I,A-II) imply that the apoA-I and lipid of Lp(A-I) and Lp(A-I,A-II) are not fully equilibrated.
AB - HDL subspecies Lp(A-I) and Lp(A-I,A-II) have different anti-atherogenic potentials. To determine the role of lipoprotein lipase (LPL) and hepatic lipase (HL) in regulating these particles, we measured these enzyme activities in 28 healthy subjects with well-controlled Type 1 diabetes, and studied their relationship with Lp(A-I) and Lp(A-I,A-II). LPL was positively correlated with the apolipoprotein A-I (apoA-I), cholesterol, and phospholipid mass in total Lp(A-I), and with the apoA-I in large Lp(A-I) (r ≥ 0.58, P ≥ 0.001). HL was negatively correlated with all the above Lp(A-I) parameters plus Lp(A-I) triglyceride (r ≥ -0.53, P ≤ 0.003). No correlation was detected between LPL and Lp(A-I,A-II). However, HL was inversely correlated with total Lp(A-I,A-II) phospholipid, and with large Lp(A-I,A-II) (r ≥ 0.50, P ≤ 0.006). Similar studies were performed with phospholipid transfer protein (PLTP). Only total Lp(A-I) triglyceride in women (not men) (r = 0.71, P = 0.009) was significantly correlated with PLTP activity. These observations indicate that LPL and HL play major roles in determining the level and composition of plasma Lp(A-I), particularly large Lp(A-I), but not with Lp (A-I,A-II) level. Furthermore, select correlations of LPL and/or HL with the apoA-I, cholesterol, and triglyceride of Lp(A-I) but not Lp(A-I,A-II) imply that the apoA-I and lipid of Lp(A-I) and Lp(A-I,A-II) are not fully equilibrated.
KW - High density lipoprotein size profile
KW - Phospholipid transfer protein
KW - Type 1 diabetes
UR - http://www.scopus.com/inward/record.url?scp=0142010584&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0142010584&partnerID=8YFLogxK
U2 - 10.1194/jlr.M300091-JLR200
DO - 10.1194/jlr.M300091-JLR200
M3 - Article
C2 - 12777470
AN - SCOPUS:0142010584
SN - 0022-2275
VL - 44
SP - 1552
EP - 1558
JO - Journal of lipid research
JF - Journal of lipid research
IS - 8
ER -