Liposome-encapsulated curcumin suppresses neuroblastoma growth through nuclear factor-kappa B inhibition

Wayne S. Orr, Jason W. Denbo, Karim R. Saab, Adrianne L. Myers, Catherine Y. Ng, Junfang Zhou, Christopher L. Morton, Lawrence M. Pfeffer, Andrew M. Davidoff

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Background: Nuclear factor-κB (NF-κB) has been implicated in tumor cell proliferation and survival and in tumor angiogenesis. We sought to evaluate the effects of curcumin, an inhibitor of NF-κB, on a xenograft model of disseminated neuroblastoma. Methods: For in vitro studies, neuroblastoma cell lines NB1691, CHLA-20, and SK-N-AS were treated with various doses of liposomal curcumin. Disseminated neuroblastoma was established in vivo by tail vein injection of NB1691-luc cells into SCID mice, which were then treated with 50 mg/kg/day of liposomal curcumin 5 days/week intraperitoneally. Results: Curcumin suppressed NF-κB activation and proliferation of all neuroblastoma cell lines in vitro. In vivo, curcumin treatment resulted in a significant decrease in disseminated tumor burden. Curcumin-treated tumors had decreased NF-κB activity and an associated significant decrease in tumor cell proliferation and an increase in tumor cell apoptosis, as well as a decrease in tumor vascular endothelial growth factor levels and microvessel density. Conclusion: Liposomal curcumin suppressed neuroblastoma growth, with treated tumors showing a decrease in NF-κB activity. Our results suggest that liposomal curcumin may be a viable option for the treatment of neuroblastoma that works via inhibiting the NF-κB pathway.

Original languageEnglish (US)
Pages (from-to)736-744
Number of pages9
JournalSurgery
Volume151
Issue number5
DOIs
StatePublished - May 2012

Bibliographical note

Funding Information:
Supported by the Assisi Foundation of Memphis , the U.S. Public Health Service Childhood Solid Tumor Program Project Grant No. CA23099 , the Cancer Center Support Grant No. 21766 from the National Cancer Institute , Grant No. CA133322 from National Cancer Institute , and by the American Lebanese Syrian Associated Charities (ALSAC) .

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