TY - JOUR
T1 - LIS1
T2 - From cortical malformation to essential protein of cellular dynamics
AU - Leventer, Richard J.
AU - Cardoso, Carlos
AU - Ledbetter, David H.
AU - Dobyns, William B.
PY - 2001/9/1
Y1 - 2001/9/1
N2 - The LIS1 gene was cloned following the study of children with lissencephaly and cytogenetic abnormalities involving chromosome 17p, however, the role of the LIS1 protein in normal cortical development is not precisely defined. LIS1 is a component of evolutionarily conserved intracellular multiprotein complexes and recent literature shows that these complexes are essential, not only for neuronal migration, but they might also be fundamental components of the machinery for cell proliferation and intracellular transport.
AB - The LIS1 gene was cloned following the study of children with lissencephaly and cytogenetic abnormalities involving chromosome 17p, however, the role of the LIS1 protein in normal cortical development is not precisely defined. LIS1 is a component of evolutionarily conserved intracellular multiprotein complexes and recent literature shows that these complexes are essential, not only for neuronal migration, but they might also be fundamental components of the machinery for cell proliferation and intracellular transport.
UR - http://www.scopus.com/inward/record.url?scp=0035451327&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035451327&partnerID=8YFLogxK
U2 - 10.1016/S0166-2236(00)01887-7
DO - 10.1016/S0166-2236(00)01887-7
M3 - Review article
C2 - 11506866
AN - SCOPUS:0035451327
SN - 0166-2236
VL - 24
SP - 489
EP - 492
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 9
ER -