Localization of protein phosphokinase activities in the nucleolus distinct from extra-nucleolar regions in rat ventral prostate nuclei

M. J. Wilson, K. Ahmed

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Rat ventral prostate nucleoli contain protein phosphokinase(s) which have distinctly different characteristics from protein phosphokinase(s) localized in the extra-nucleolar regions of the nucleus. The differences pertain to pH vs activity profiles and activation by divalent cations, utilizing dephospho-phosvitin as substrate. Lysine-rich and arginine-rich F3 histones are also phosphorylated by nucleolar protein phosphokinase(s). Phosphorylation of histones by either nucleolar or extra-nucleolar fractions was not stimulated by cAMP, whereas that of phosvitin was slightly inhibited.

Original languageEnglish (US)
Pages (from-to)261-266
Number of pages6
JournalExperimental Cell Research
Volume93
Issue number2
DOIs
StatePublished - Jul 1975

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