Localization of tritium-labeled digoxin in the eye of the rat was investigated, using autoradiographic and scintillographic techniques. The iris and inner retinal layers were found to be the primary binding sites of digitalis. Negligible amounts of radioactivity were found in the outer retinal layers, brain, and optic nerve.
Bibliographical noteFunding Information:
From the Department of Ophthalmology, Northwestern University Medical School, Chicago, Illinois. This study was supported in part by Public Health Service Research Grant R01EY00389 from the National Eye Institute, a National Society for the Prevention of Blindness Research Grant and The Carrie Blanche Levy Fund for Experimental Studies in Ophthalmology of the Chicago Wesley Memorial Hospital.