Abstract
The biochemical processes of cell membranes are sensitive to the geometry of the lipid bilayer. We show how plasmonic "nanowells" provide label-free real-time analysis of molecules on membranes with detection of preferential binding at negative curvature. It is demonstrated that norovirus accumulate in invaginations due to multivalent interactions with glycosphingolipids.
Original language | English (US) |
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Pages (from-to) | 15080-15085 |
Number of pages | 6 |
Journal | Nanoscale |
Volume | 7 |
Issue number | 37 |
DOIs | |
State | Published - Oct 7 2015 |
Bibliographical note
Publisher Copyright:© 2015 The Royal Society of Chemistry.