Long-Term Post-Discharge Risks in Older Survivors of Myocardial Infarction with and Without Out-of-Hospital Cardiac Arrest

Christopher B. Fordyce; Tracy Y. Wang; Anita Y. Chen; Laine Thomas; Christopher B. Granger; Benjamin M. Scirica; Timothy D. Henry; Graham C. Wong; Krishnan Ramanathan; Carolina M. Hansen; Kristian Kragholm; Eric D. Peterson; Monique L. Anderson

doi:10.1016/j.jacc.2016.02.044

Long-Term Post-Discharge Risks in Older Survivors of Myocardial Infarction with and Without Out-of-Hospital Cardiac Arrest

Christopher B. Fordyce, Tracy Y. Wang, Anita Y. Chen, Laine Thomas, Christopher B. Granger, Benjamin M. Scirica, Timothy D. Henry, Graham C. Wong, Krishnan Ramanathan, Carolina M. Hansen, Kristian Kragholm, Eric D. Peterson, Monique L. Anderson

Medicine - Cardiology Division

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Background Out-of-hospital cardiac arrest (OHCA) associated with acute myocardial infarction (MI) confers high in-hospital mortality; however, among those patients who survive, little is known regarding their post-discharge mortality and health care use rates. Objectives The purpose of this study was to determine 1-year survival and readmission rates after hospital discharge of older MI survivors with and without OHCA. Methods Using linked Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With the Guidelines and Medicare data, this study analyzed 54,860 patients with MI who were older than 65 years of age and who had been discharged alive from 545 U.S. hospitals between April 2011 and December 2012. Multivariable models examined the associations between MI-associated OHCA and 1-year post-discharge mortality or all-cause readmission rates. Patients discharged to hospice were excluded, given their known poor prognosis. Results Following hospital discharge, compared with older MI survivors without OHCA (n = 54,219), those with OHCA (n = 641, 1.2%) were more likely to be younger, male, and smokers, but less likely to have diabetes, heart failure, or prior revascularization. OHCA patients presented more often with ST-segment elevation myocardial infarction (63.2% vs. 29.6%) and cardiogenic shock (29.0% vs. 2.2%); however, among in-hospital MI survivors, OHCA was not associated with 1-year post-discharge mortality (unadjusted 13.8% vs. 15.8%, p = 0.17, adjusted hazard ratio [HR]: 0.89; 95% confidence interval [CI]: 0.68 to 1.15). In contrast, MI survivors with OHCA actually had lower unadjusted and adjusted risk of the composite outcome of 1-year mortality or all-cause readmission than patients without OHCA (44.0% vs. 50.0%, p = 0.03, adjusted HR: 0.84; 95% CI: 0.72 to 0.97). Conclusions Among older patients with MI who survived to hospital discharge and were not discharged to hospice, those presenting with OHCA did not have higher 1-year mortality or health care use rates compared with those MI survivors without OHCA. These findings show that the early risk of adverse events in patients with OHCA does not persist after hospital discharge, and they support efforts to improve initial survival rates of older patients with MI and OHCA.

Original language	English (US)
Pages (from-to)	1981-1990
Number of pages	10
Journal	Journal of the American College of Cardiology
Volume	67
Issue number	17
DOIs	https://doi.org/10.1016/j.jacc.2016.02.044
State	Published - May 3 2016

Bibliographical note

Funding Information:
The National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With The Guidelines (ACTION Registry-GWTG) (19) is a voluntary quality improvement registry in the United States that includes consecutive patients admitted to participating hospitals with ST-segment elevation MI (STEMI) or non–ST-segment elevation MI (NSTEMI). This program is sponsored by the American College of Cardiology and the American Heart Association. The National Cardiovascular Data Registry data quality program includes data abstraction training, data quality thresholds for inclusion, site data quality feedback reports, independent auditing, and data validation. Auditing of data has demonstrated chart review agreement of >93% (20) . At participating sites, this registry was either approved by an Institutional Review Board or considered quality assurance data and was therefore not subject to Institutional Review Board approval on the basis of on individual site determinations. The Duke Clinical Research Institute (Durham, North Carolina) serves as the data coordinating center to analyze de-identified data for research purposes. We linked Centers for Medicare and Medicaid Services claims data through the end of 2012 with patients ≥65 years old in ACTION Registry-GWTG by using the following indirect identifiers: date of birth, sex, hospital identifier, date of admission, and date of discharge. Details describing the linkage process have been previously published (21) . Our linkage extended the reach of ACTION Registry-GWTG to assess post-discharge outcomes.

Publisher Copyright:
© 2016 American College of Cardiology Foundation.

Keywords

cardiac arrest
myocardial infarction
older
prognosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1016/j.jacc.2016.02.044

OpenUrl availability

Full text

Cite this

Fordyce, C. B., Wang, T. Y., Chen, A. Y., Thomas, L., Granger, C. B., Scirica, B. M., Henry, T. D., Wong, G. C., Ramanathan, K., Hansen, C. M., Kragholm, K., Peterson, E. D., & Anderson, M. L. (2016). Long-Term Post-Discharge Risks in Older Survivors of Myocardial Infarction with and Without Out-of-Hospital Cardiac Arrest. Journal of the American College of Cardiology, 67(17), 1981-1990. https://doi.org/10.1016/j.jacc.2016.02.044

Fordyce, CB, Wang, TY, Chen, AY, Thomas, L, Granger, CB, Scirica, BM, Henry, TD, Wong, GC, Ramanathan, K, Hansen, CM, Kragholm, K, Peterson, ED & Anderson, ML 2016, 'Long-Term Post-Discharge Risks in Older Survivors of Myocardial Infarction with and Without Out-of-Hospital Cardiac Arrest', Journal of the American College of Cardiology, vol. 67, no. 17, pp. 1981-1990. https://doi.org/10.1016/j.jacc.2016.02.044

@article{4498fd332b974151a13d10ceac80ddb2,

title = "Long-Term Post-Discharge Risks in Older Survivors of Myocardial Infarction with and Without Out-of-Hospital Cardiac Arrest",

abstract = "Background Out-of-hospital cardiac arrest (OHCA) associated with acute myocardial infarction (MI) confers high in-hospital mortality; however, among those patients who survive, little is known regarding their post-discharge mortality and health care use rates. Objectives The purpose of this study was to determine 1-year survival and readmission rates after hospital discharge of older MI survivors with and without OHCA. Methods Using linked Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With the Guidelines and Medicare data, this study analyzed 54,860 patients with MI who were older than 65 years of age and who had been discharged alive from 545 U.S. hospitals between April 2011 and December 2012. Multivariable models examined the associations between MI-associated OHCA and 1-year post-discharge mortality or all-cause readmission rates. Patients discharged to hospice were excluded, given their known poor prognosis. Results Following hospital discharge, compared with older MI survivors without OHCA (n = 54,219), those with OHCA (n = 641, 1.2%) were more likely to be younger, male, and smokers, but less likely to have diabetes, heart failure, or prior revascularization. OHCA patients presented more often with ST-segment elevation myocardial infarction (63.2% vs. 29.6%) and cardiogenic shock (29.0% vs. 2.2%); however, among in-hospital MI survivors, OHCA was not associated with 1-year post-discharge mortality (unadjusted 13.8% vs. 15.8%, p = 0.17, adjusted hazard ratio [HR]: 0.89; 95% confidence interval [CI]: 0.68 to 1.15). In contrast, MI survivors with OHCA actually had lower unadjusted and adjusted risk of the composite outcome of 1-year mortality or all-cause readmission than patients without OHCA (44.0% vs. 50.0%, p = 0.03, adjusted HR: 0.84; 95% CI: 0.72 to 0.97). Conclusions Among older patients with MI who survived to hospital discharge and were not discharged to hospice, those presenting with OHCA did not have higher 1-year mortality or health care use rates compared with those MI survivors without OHCA. These findings show that the early risk of adverse events in patients with OHCA does not persist after hospital discharge, and they support efforts to improve initial survival rates of older patients with MI and OHCA.",

keywords = "cardiac arrest, myocardial infarction, older, prognosis",

author = "Fordyce, {Christopher B.} and Wang, {Tracy Y.} and Chen, {Anita Y.} and Laine Thomas and Granger, {Christopher B.} and Scirica, {Benjamin M.} and Henry, {Timothy D.} and Wong, {Graham C.} and Krishnan Ramanathan and Hansen, {Carolina M.} and Kristian Kragholm and Peterson, {Eric D.} and Anderson, {Monique L.}",

note = "Funding Information: The National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With The Guidelines (ACTION Registry-GWTG) (19) is a voluntary quality improvement registry in the United States that includes consecutive patients admitted to participating hospitals with ST-segment elevation MI (STEMI) or non–ST-segment elevation MI (NSTEMI). This program is sponsored by the American College of Cardiology and the American Heart Association. The National Cardiovascular Data Registry data quality program includes data abstraction training, data quality thresholds for inclusion, site data quality feedback reports, independent auditing, and data validation. Auditing of data has demonstrated chart review agreement of >93% (20) . At participating sites, this registry was either approved by an Institutional Review Board or considered quality assurance data and was therefore not subject to Institutional Review Board approval on the basis of on individual site determinations. The Duke Clinical Research Institute (Durham, North Carolina) serves as the data coordinating center to analyze de-identified data for research purposes. We linked Centers for Medicare and Medicaid Services claims data through the end of 2012 with patients ≥65 years old in ACTION Registry-GWTG by using the following indirect identifiers: date of birth, sex, hospital identifier, date of admission, and date of discharge. Details describing the linkage process have been previously published (21) . Our linkage extended the reach of ACTION Registry-GWTG to assess post-discharge outcomes. Publisher Copyright: {\textcopyright} 2016 American College of Cardiology Foundation.",

year = "2016",

month = may,

day = "3",

doi = "10.1016/j.jacc.2016.02.044",

language = "English (US)",

volume = "67",

pages = "1981--1990",

journal = "Journal of the American College of Cardiology",

issn = "0735-1097",

publisher = "Elsevier USA",

number = "17",

}

TY - JOUR

T1 - Long-Term Post-Discharge Risks in Older Survivors of Myocardial Infarction with and Without Out-of-Hospital Cardiac Arrest

AU - Fordyce, Christopher B.

AU - Wang, Tracy Y.

AU - Chen, Anita Y.

AU - Thomas, Laine

AU - Granger, Christopher B.

AU - Scirica, Benjamin M.

AU - Henry, Timothy D.

AU - Wong, Graham C.

AU - Ramanathan, Krishnan

AU - Hansen, Carolina M.

AU - Kragholm, Kristian

AU - Peterson, Eric D.

AU - Anderson, Monique L.

N1 - Funding Information: The National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With The Guidelines (ACTION Registry-GWTG) (19) is a voluntary quality improvement registry in the United States that includes consecutive patients admitted to participating hospitals with ST-segment elevation MI (STEMI) or non–ST-segment elevation MI (NSTEMI). This program is sponsored by the American College of Cardiology and the American Heart Association. The National Cardiovascular Data Registry data quality program includes data abstraction training, data quality thresholds for inclusion, site data quality feedback reports, independent auditing, and data validation. Auditing of data has demonstrated chart review agreement of >93% (20) . At participating sites, this registry was either approved by an Institutional Review Board or considered quality assurance data and was therefore not subject to Institutional Review Board approval on the basis of on individual site determinations. The Duke Clinical Research Institute (Durham, North Carolina) serves as the data coordinating center to analyze de-identified data for research purposes. We linked Centers for Medicare and Medicaid Services claims data through the end of 2012 with patients ≥65 years old in ACTION Registry-GWTG by using the following indirect identifiers: date of birth, sex, hospital identifier, date of admission, and date of discharge. Details describing the linkage process have been previously published (21) . Our linkage extended the reach of ACTION Registry-GWTG to assess post-discharge outcomes. Publisher Copyright: © 2016 American College of Cardiology Foundation.

PY - 2016/5/3

Y1 - 2016/5/3

N2 - Background Out-of-hospital cardiac arrest (OHCA) associated with acute myocardial infarction (MI) confers high in-hospital mortality; however, among those patients who survive, little is known regarding their post-discharge mortality and health care use rates. Objectives The purpose of this study was to determine 1-year survival and readmission rates after hospital discharge of older MI survivors with and without OHCA. Methods Using linked Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With the Guidelines and Medicare data, this study analyzed 54,860 patients with MI who were older than 65 years of age and who had been discharged alive from 545 U.S. hospitals between April 2011 and December 2012. Multivariable models examined the associations between MI-associated OHCA and 1-year post-discharge mortality or all-cause readmission rates. Patients discharged to hospice were excluded, given their known poor prognosis. Results Following hospital discharge, compared with older MI survivors without OHCA (n = 54,219), those with OHCA (n = 641, 1.2%) were more likely to be younger, male, and smokers, but less likely to have diabetes, heart failure, or prior revascularization. OHCA patients presented more often with ST-segment elevation myocardial infarction (63.2% vs. 29.6%) and cardiogenic shock (29.0% vs. 2.2%); however, among in-hospital MI survivors, OHCA was not associated with 1-year post-discharge mortality (unadjusted 13.8% vs. 15.8%, p = 0.17, adjusted hazard ratio [HR]: 0.89; 95% confidence interval [CI]: 0.68 to 1.15). In contrast, MI survivors with OHCA actually had lower unadjusted and adjusted risk of the composite outcome of 1-year mortality or all-cause readmission than patients without OHCA (44.0% vs. 50.0%, p = 0.03, adjusted HR: 0.84; 95% CI: 0.72 to 0.97). Conclusions Among older patients with MI who survived to hospital discharge and were not discharged to hospice, those presenting with OHCA did not have higher 1-year mortality or health care use rates compared with those MI survivors without OHCA. These findings show that the early risk of adverse events in patients with OHCA does not persist after hospital discharge, and they support efforts to improve initial survival rates of older patients with MI and OHCA.

AB - Background Out-of-hospital cardiac arrest (OHCA) associated with acute myocardial infarction (MI) confers high in-hospital mortality; however, among those patients who survive, little is known regarding their post-discharge mortality and health care use rates. Objectives The purpose of this study was to determine 1-year survival and readmission rates after hospital discharge of older MI survivors with and without OHCA. Methods Using linked Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With the Guidelines and Medicare data, this study analyzed 54,860 patients with MI who were older than 65 years of age and who had been discharged alive from 545 U.S. hospitals between April 2011 and December 2012. Multivariable models examined the associations between MI-associated OHCA and 1-year post-discharge mortality or all-cause readmission rates. Patients discharged to hospice were excluded, given their known poor prognosis. Results Following hospital discharge, compared with older MI survivors without OHCA (n = 54,219), those with OHCA (n = 641, 1.2%) were more likely to be younger, male, and smokers, but less likely to have diabetes, heart failure, or prior revascularization. OHCA patients presented more often with ST-segment elevation myocardial infarction (63.2% vs. 29.6%) and cardiogenic shock (29.0% vs. 2.2%); however, among in-hospital MI survivors, OHCA was not associated with 1-year post-discharge mortality (unadjusted 13.8% vs. 15.8%, p = 0.17, adjusted hazard ratio [HR]: 0.89; 95% confidence interval [CI]: 0.68 to 1.15). In contrast, MI survivors with OHCA actually had lower unadjusted and adjusted risk of the composite outcome of 1-year mortality or all-cause readmission than patients without OHCA (44.0% vs. 50.0%, p = 0.03, adjusted HR: 0.84; 95% CI: 0.72 to 0.97). Conclusions Among older patients with MI who survived to hospital discharge and were not discharged to hospice, those presenting with OHCA did not have higher 1-year mortality or health care use rates compared with those MI survivors without OHCA. These findings show that the early risk of adverse events in patients with OHCA does not persist after hospital discharge, and they support efforts to improve initial survival rates of older patients with MI and OHCA.

KW - cardiac arrest

KW - myocardial infarction

KW - older

KW - prognosis

UR - http://www.scopus.com/inward/record.url?scp=84964963440&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964963440&partnerID=8YFLogxK

U2 - 10.1016/j.jacc.2016.02.044

DO - 10.1016/j.jacc.2016.02.044

M3 - Article

C2 - 27126525

AN - SCOPUS:84964963440

SN - 0735-1097

VL - 67

SP - 1981

EP - 1990

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

IS - 17

ER -

Long-Term Post-Discharge Risks in Older Survivors of Myocardial Infarction with and Without Out-of-Hospital Cardiac Arrest

Abstract

Bibliographical note

Keywords

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this