Longitudinal ambulatory blood pressure monitoring for a sequential chronobiologic assessment of losartan effects

Y. Watanabe, G. Cornélissen, K. Otsuka, J. Siegelová, J. Jančík, F. Halberg

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

In order to assess the efficacy of losartan for the treatment of hypertension, 13 patients had their blood pressure and heart rate measured around the clock with an ambulatory monitor for one to 15 days before and then during treatment that lasted from one to 14 weeks. Losartan was administered alone or in combination with a diuretic. Parameter tests and a self-starting cumulative sum (CUSUM) control chart, which were used for individual assessment of the patient's response to treatment, showed large inter-individual differences. On the other hand, paired t-tests used for group assessment revealed that treatment with losartan was associated with only a small decrease in diastolic blood pressure. The results indicate the need for monitoring blood pressure over sufficiently long spans so that the patient's response can be reliably assessed on an individual basis.

Original languageEnglish (US)
Pages (from-to)129-134
Number of pages6
JournalScripta Medica Facultatis Medicae Universitatis Brunensis Masarykianae
Volume75
Issue number3
StatePublished - Jan 1 2002

Keywords

  • Ambulatory monitoring
  • Blood pressure
  • Essential hypertension
  • Losartan

Fingerprint Dive into the research topics of 'Longitudinal ambulatory blood pressure monitoring for a sequential chronobiologic assessment of losartan effects'. Together they form a unique fingerprint.

Cite this