Longitudinal associations of midlife accelerometer determined sedentary behavior and physical activity with cognitive function: The cardia study

Kara M. Whitaker, Dong Zhang, Kelley Pettee Gabriel, Monica Ahrens, Barbara Sternfeld, Stephen Sidney, David R. Jacobs, Priya Palta, Kristine Yaffe

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: To determine if accelerometer measured sedentary behavior (SED), light-intensity physical activity (LPA), and moderate-to-vigorous–intensity physical activity (MVPA) in midlife is prospectively associated with cognitive function. METHODS AND RESULTS: Participants were 1970 adults enrolled in the CARDIA (Coronary Artery Risk Development in Young Adults) study who wore an accelerometer in 2005 to 2006 (ages 38–50 years) and had cognitive function assessments completed 5 and/or 10 years later. SED, LPA, and MVPA were measured by an ActiGraph 7164 accelerometer. Cognitive function tests included the Digit Symbol Substitution Test, Rey Auditory Verbal Learning Test, and Stroop Test. Compositional isotemporal substitution analysis examined associations of SED, LPA, and MVPA with repeated measures of the cognitive function standardized scores. In men, statistical reallocation of 30 minutes of LPA with 30 minutes of MVPA resulted in an estimated difference of SD 0.07 (95% CI, 0.01–0.14), SD 0.09 (95% CI, 0.02–0.17), and SD −0.11 (95% CI, −0.19 to −0.04) in the Digit Symbol Substitution Test, Rey Auditory Verbal Learning Test, and Stroop scores, respectively, indicating better performance. Associations were similar when reallocating time in SED with MVPA, but results were less robust. Reallocation of time in SED with LPA resulted in an estimated difference of SD −0.05 (95% CI, −0.06 to −0.03), SD −0.03 (95% CI, −0.05 to −0.01), and SD 0.05 (95% CI, 0.03– 0.07) in the Digit Symbol Substitution Test, Rey Auditory Verbal Learning Test, and Stroop scores, respectively, indicating worse performance. Associations were largely nonsignificant among women. CONCLUSIONS: Our findings support the idea that for men, higher-intensity activities (MVPA) may be necessary in midlife to observe beneficial associations with cognition.

Original languageEnglish (US)
Article numbere018350
Pages (from-to)1-18
Number of pages18
JournalJournal of the American Heart Association
Volume10
Issue number3
DOIs
StatePublished - 2021

Bibliographical note

Funding Information:
The Coronary Artery Risk Development in Young Adults Study (CARDIA) is conducted and supported by the National Heart, Lung, and Blood Institute (NHLBI) in collaboration with the University of Alabama at Birmingham (HHSN268201800005I and HHSN268201800007I), Northwestern University (HHSN268201800003I), University of Minnesota (HHSN268201800006I), and Kaiser Foundation Research Institute (HHSN268201800004I). Accelerometer data collection was supported by grant R01 HL078972 from the NHLBI. P.P. is supported by grant R00AG052830 from the National Institute of Aging.

Publisher Copyright:
© 2021 The Authors.

Keywords

  • Cognition
  • Compositional isotemporal substitution
  • Epidemiology
  • Physical activity
  • Sedentary behaviour

PubMed: MeSH publication types

  • Journal Article

Fingerprint

Dive into the research topics of 'Longitudinal associations of midlife accelerometer determined sedentary behavior and physical activity with cognitive function: The cardia study'. Together they form a unique fingerprint.

Cite this