TY - JOUR
T1 - Low-dose sultamicillin versus amoxicillin-clavulanic acid in the treatment of acute bacterial sinusitis in adults
T2 - A randomized clinical trial
AU - Hasibi, Mehrdad
AU - Mohraz, Minoo
AU - Haji-Abdolbaghi, Mahboubeh
AU - Rasoolinejad, Mehrnaz
AU - Rashidi, Armin
AU - Abouzari, Mehdi
PY - 2007/3
Y1 - 2007/3
N2 - Several pathogens implicated in acute bacterial sinusitis have developed a notable incidence of antibiotic resistance usually through the production of a beta-lactamase. The purpose of this study was to compare the effectiveness of amoxicillin-clavulanic acid with that of low-dose sultamicillin in the treatment of acute bacterial sinusitis. Patients with acute sinusitis were randomly allocated in either of 2 groups: patients in group A (n = 21) received 625 mg amoxicillin-clavulanic acid 3 times daily for 10 days, and group B (n = 23) received 375 mg oral sultamicillin 2 times daily for the same duration. The 2 groups were not statistically different regarding age and sex. In group A, both intention-to-treat and per-protocol cure rates were 85.7%, whereas the corresponding figures in group B were 82.6% and 86.4%, respectively. Cure rates were not statistically different between the 2 groups, and side effects in group B were not significantly more common than in group A. In conclusion, low-dose sultamicillin can be considered as an effective and safe therapeutic regimen for acute bacterial sinusitis.
AB - Several pathogens implicated in acute bacterial sinusitis have developed a notable incidence of antibiotic resistance usually through the production of a beta-lactamase. The purpose of this study was to compare the effectiveness of amoxicillin-clavulanic acid with that of low-dose sultamicillin in the treatment of acute bacterial sinusitis. Patients with acute sinusitis were randomly allocated in either of 2 groups: patients in group A (n = 21) received 625 mg amoxicillin-clavulanic acid 3 times daily for 10 days, and group B (n = 23) received 375 mg oral sultamicillin 2 times daily for the same duration. The 2 groups were not statistically different regarding age and sex. In group A, both intention-to-treat and per-protocol cure rates were 85.7%, whereas the corresponding figures in group B were 82.6% and 86.4%, respectively. Cure rates were not statistically different between the 2 groups, and side effects in group B were not significantly more common than in group A. In conclusion, low-dose sultamicillin can be considered as an effective and safe therapeutic regimen for acute bacterial sinusitis.
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U2 - 10.1097/01.idc.0000240864.20306.80
DO - 10.1097/01.idc.0000240864.20306.80
M3 - Article
AN - SCOPUS:34247153049
SN - 1056-9103
VL - 15
SP - 104
EP - 105
JO - Infectious Diseases in Clinical Practice
JF - Infectious Diseases in Clinical Practice
IS - 2
ER -