Low-Frequency Repetitive Transcranial Magnetic Stimulation Targeted to Premotor Cortex Followed by Primary Motor Cortex Modulates Excitability Differently Than Premotor Cortex or Primary Motor Cortex Stimulation Alone

Mo Chen, Huiqiong Deng, Rebekah L. Schmidt, Teresa J. Kimberley

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Objectives The excitability of primary motor cortex (M1) can be modulated by applying low-frequency repetitive transcranial magnetic stimulation (rTMS) over M1 or premotor cortex (PMC). A comparison of inhibitory effect between the two locations has been reported with inconsistent results. This study compared the response secondary to rTMS applied over M1, PMC, and a combined PMC + M1 stimulation approach which first targets stimulation over PMC then M1. Materials and Methods Ten healthy participants were recruited for a randomized, cross-over design with a one-week washout between visits. Each visit consisted of a pretest, an rTMS intervention, and a post-test. Outcome measures included short interval intracortical inhibition (SICI), intracortical facilitation (ICF), and cortical silent period (CSP). Participants received one of the three interventions in random order at each visit including: 1-Hz rTMS at 90% of resting motor threshold to: M1 (1200 pulses), PMC (1200 pulses), and PMC + M1 (600 pulses each, 1200 total). Results PMC + M1 stimulation resulted in significantly greater inhibition than the other locations for ICF (P = 0.005) and CSP (P < 0.001); for SICI, increased inhibition (group effect) was not observed after any of the three interventions, and there was no significant difference between the three interventions. Conclusion The results indicate that PMC + M1 stimulation may modulate brain excitability differently from PMC or M1 alone. CSP was the assessment measure most sensitive to changes in inhibition and was able to distinguish between different inhibitory protocols. This work presents a novel procedure that may have positive implications for therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)678-684
Number of pages7
JournalNeuromodulation
Volume18
Issue number8
DOIs
StatePublished - Dec 1 2015

Bibliographical note

Funding Information:
Research reported in this publication was supported by the Minnesota Medical Foundation (MMF) Faculty Development Grant 4090-9224-12 and National Center for Advancing Translational Sciences Award Number UL1TR000114 of the National Institutes of Health. All funding sources supporting this work are acknowledged. We acknowledge Sara Sokolowski, Karla Wallner, Lindsey Weyer, ThomasWilliams, and CaitlinWooldridge for their help with the data collection in this work.

Keywords

  • Brain excitability
  • neuromodulation
  • premotor cortex
  • primary motor cortex
  • repetitive transcranial magnetic stimulation

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