Low molecular weight B cell growth factor induces proliferation of human B cell precursor acute lymphoblastic leukemias

B. Wormann, S. R. Mehta, A. L. Maizel, Tucker W LeBien

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23 Scopus citations

Abstract

Experiments were conducted to determine the effect of low mol wt B cell growth factor (L-BCGF) on B cell precursor acute lymphoblastic leukemia (ALL). L-BCGF induced a significant increase in 3H-TdR incorporation in 28 of 37 bone marrow aspirates from patients with B cell precursor ALL, with stimulation indices ranging from 2 to 129. Fluorescence-activated cell sorting confirmed that in five of seven patients the common acute lymphoblastic leukemia antigen (CALLA)/CD10 positive leukemic cells were responding directly to L-BCGF. L-BCGF was capable of inducing, in some patients, an increase in absolute viable cells and could also induced colony formation in vitro. The response of B cell precursor ALL was not attributable to β IL 1, IL 2, or γ interferon. These results indicate that the majority of B cell precursor ALL undergo a proliferative response to L-BCGF, suggesting a regulatory role for this lymphokine in the growth of B cell precursors.

Original languageEnglish (US)
Pages (from-to)132-138
Number of pages7
JournalBlood
Volume70
Issue number1
DOIs
StatePublished - 1987

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