TY - JOUR
T1 - Lung fibrosis and emphysema
T2 - Divergent responses to a common injury?
AU - Niewoehner, Dennis E.
AU - Hoidal, John R.
PY - 1982/1/1
Y1 - 1982/1/1
N2 - Cadmium chloride, administered intratracheally to golden Syrian hamsters, causes an acute lung injury which evolves into a lesion with functional and morphological features of diffuse fibrosis. With simultaneous feeding of a lathyrogen, β-aminoproprionitrile, this same injury evolves into functional and morphological changes of bullous emphysema. These results suggest that the same lung injury might result in either fibrosis or emphysema, connective tissue synthesis during the healing phase being the critical determinant.
AB - Cadmium chloride, administered intratracheally to golden Syrian hamsters, causes an acute lung injury which evolves into a lesion with functional and morphological features of diffuse fibrosis. With simultaneous feeding of a lathyrogen, β-aminoproprionitrile, this same injury evolves into functional and morphological changes of bullous emphysema. These results suggest that the same lung injury might result in either fibrosis or emphysema, connective tissue synthesis during the healing phase being the critical determinant.
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U2 - 10.1126/science.7089570
DO - 10.1126/science.7089570
M3 - Article
C2 - 7089570
AN - SCOPUS:0019945992
SN - 0036-8075
VL - 217
SP - 359
EP - 360
JO - Science
JF - Science
IS - 4557
ER -