Macrophages in mice acutely infected with lymphocytic choriomeningitis virus are primed for nitric oxide synthesis

Eric A. Butz, Bruce S. Hostager, Peter Southern

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Following infection of adult mice with lymphocytic choriomeningitis virus (LCMV) there is a well documented suppression of T-cell and B-cell functions concurrent with the strong anti-LCMV immune response. Macrophages have been shown to be infected and activated during acute LCMV infection and there is some evidence to indicate that there is altered antigen presentation in acutely infected mice. We have examined nitric oxide (NO) production by splenic macrophages during acute infection of adult mice. Our results show that these macrophages are primed for production of NO, that the inducible production of NO parallels the immune suppression, and that NO production is dependent on the presence of IFNγ. However, neither in vivo nor in vitro treatment with N-monomethyl-L-arginine (NMA), a specific inhibitor of nitric oxide synthase, altered the induction or maintenance of virus-induced immune suppression in mice acutely infected with LCMV.

Original languageEnglish (US)
Pages (from-to)283-295
Number of pages13
JournalMicrobial Pathogenesis
Volume16
Issue number4
DOIs
StatePublished - Apr 1994

Bibliographical note

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

  • Immunosuppression
  • Lymphocytic choriomeningitis virus
  • Nitric oxide

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