Macular pigment density and distribution: Comparison of fundus autofluorescence with minimum motion photometry

Anthony G. Robson, Jack D. Moreland, Daniel Pauleikhoff, Tony Morrissey, Graham E. Holder, Fred W. Fitzke, Alan C. Bird, Frederik J.G.M. Van Kuijk

Research output: Contribution to journalArticlepeer-review

95 Scopus citations

Abstract

Macular pigment (MP) distribution profiles were measured for 18 subjects using a Moreland anomaloscope modified for motion photometry. The total amount of MP within the central 7° was estimated from the distribution profile by numerical integration. Fundus autofluorescence images were obtained for eight of these subjects using a scanning laser ophthalmoscope. Peak optical density of MP increased with the total amount present, but the correlation was weakened by inter-subject differences in MP distribution. The mean MP distribution derived from mean grey-scale profiles of fundus autofluorescence images correlated closely with that obtained psychophysically (r=0.96). Autofluorescence imaging provides a fast non-invasive method for assessing MP in vivo.

Original languageEnglish (US)
Pages (from-to)1765-1775
Number of pages11
JournalVision Research
Volume43
Issue number16
DOIs
StatePublished - Jul 2003

Bibliographical note

Funding Information:
A.G. Robson is supported by The Foundation Fighting Blindness. F.J.G.M. van Kuijk is supported by Research to prevent blindness. We are indebted to Professor J.J. Kulikowski and Chris Hogg for their help in preliminary studies.

Keywords

  • Age-related macular degeneration
  • Autofluorescence
  • Imaging
  • Macular pigment
  • Motion photometry

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