Macular pigment density and distribution: Comparison of fundus autofluorescence with minimum motion photometry

Anthony G. Robson; Jack D. Moreland; Daniel Pauleikhoff; Tony Morrissey; Graham E. Holder; Fred W. Fitzke; Alan C. Bird; Frederik J.G.M. Van Kuijk

doi:10.1016/S0042-6989(03)00280-3

Macular pigment density and distribution: Comparison of fundus autofluorescence with minimum motion photometry

Anthony G. Robson, Jack D. Moreland, Daniel Pauleikhoff, Tony Morrissey, Graham E. Holder, Fred W. Fitzke, Alan C. Bird, Frederik J.G.M. Van Kuijk

Ophthalmology & Visual Neurosciences

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

Macular pigment (MP) distribution profiles were measured for 18 subjects using a Moreland anomaloscope modified for motion photometry. The total amount of MP within the central 7° was estimated from the distribution profile by numerical integration. Fundus autofluorescence images were obtained for eight of these subjects using a scanning laser ophthalmoscope. Peak optical density of MP increased with the total amount present, but the correlation was weakened by inter-subject differences in MP distribution. The mean MP distribution derived from mean grey-scale profiles of fundus autofluorescence images correlated closely with that obtained psychophysically (r=0.96). Autofluorescence imaging provides a fast non-invasive method for assessing MP in vivo.

Original language	English (US)
Pages (from-to)	1765-1775
Number of pages	11
Journal	Vision Research
Volume	43
Issue number	16
DOIs	https://doi.org/10.1016/S0042-6989(03)00280-3
State	Published - Jul 2003

Bibliographical note

Funding Information:
A.G. Robson is supported by The Foundation Fighting Blindness. F.J.G.M. van Kuijk is supported by Research to prevent blindness. We are indebted to Professor J.J. Kulikowski and Chris Hogg for their help in preliminary studies.

Keywords

Age-related macular degeneration
Autofluorescence
Imaging
Macular pigment
Motion photometry

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Macular pigment density and distribution : Comparison of fundus autofluorescence with minimum motion photometry. / Robson, Anthony G.; Moreland, Jack D.; Pauleikhoff, Daniel; Morrissey, Tony; Holder, Graham E.; Fitzke, Fred W.; Bird, Alan C.; Van Kuijk, Frederik J.G.M.

In: Vision Research, Vol. 43, No. 16, 07.2003, p. 1765-1775.

Research output: Contribution to journal › Article › peer-review

@article{952b18370de448ab8f037968ce61cc7c,

title = "Macular pigment density and distribution: Comparison of fundus autofluorescence with minimum motion photometry",

abstract = "Macular pigment (MP) distribution profiles were measured for 18 subjects using a Moreland anomaloscope modified for motion photometry. The total amount of MP within the central 7° was estimated from the distribution profile by numerical integration. Fundus autofluorescence images were obtained for eight of these subjects using a scanning laser ophthalmoscope. Peak optical density of MP increased with the total amount present, but the correlation was weakened by inter-subject differences in MP distribution. The mean MP distribution derived from mean grey-scale profiles of fundus autofluorescence images correlated closely with that obtained psychophysically (r=0.96). Autofluorescence imaging provides a fast non-invasive method for assessing MP in vivo.",

keywords = "Age-related macular degeneration, Autofluorescence, Imaging, Macular pigment, Motion photometry",

author = "Robson, {Anthony G.} and Moreland, {Jack D.} and Daniel Pauleikhoff and Tony Morrissey and Holder, {Graham E.} and Fitzke, {Fred W.} and Bird, {Alan C.} and {Van Kuijk}, {Frederik J.G.M.}",

note = "Funding Information: A.G. Robson is supported by The Foundation Fighting Blindness. F.J.G.M. van Kuijk is supported by Research to prevent blindness. We are indebted to Professor J.J. Kulikowski and Chris Hogg for their help in preliminary studies.",

year = "2003",

month = jul,

doi = "10.1016/S0042-6989(03)00280-3",

language = "English (US)",

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T2 - Comparison of fundus autofluorescence with minimum motion photometry

AU - Robson, Anthony G.

AU - Moreland, Jack D.

AU - Pauleikhoff, Daniel

AU - Morrissey, Tony

AU - Holder, Graham E.

AU - Fitzke, Fred W.

AU - Bird, Alan C.

AU - Van Kuijk, Frederik J.G.M.

N1 - Funding Information: A.G. Robson is supported by The Foundation Fighting Blindness. F.J.G.M. van Kuijk is supported by Research to prevent blindness. We are indebted to Professor J.J. Kulikowski and Chris Hogg for their help in preliminary studies.

PY - 2003/7

Y1 - 2003/7

N2 - Macular pigment (MP) distribution profiles were measured for 18 subjects using a Moreland anomaloscope modified for motion photometry. The total amount of MP within the central 7° was estimated from the distribution profile by numerical integration. Fundus autofluorescence images were obtained for eight of these subjects using a scanning laser ophthalmoscope. Peak optical density of MP increased with the total amount present, but the correlation was weakened by inter-subject differences in MP distribution. The mean MP distribution derived from mean grey-scale profiles of fundus autofluorescence images correlated closely with that obtained psychophysically (r=0.96). Autofluorescence imaging provides a fast non-invasive method for assessing MP in vivo.

AB - Macular pigment (MP) distribution profiles were measured for 18 subjects using a Moreland anomaloscope modified for motion photometry. The total amount of MP within the central 7° was estimated from the distribution profile by numerical integration. Fundus autofluorescence images were obtained for eight of these subjects using a scanning laser ophthalmoscope. Peak optical density of MP increased with the total amount present, but the correlation was weakened by inter-subject differences in MP distribution. The mean MP distribution derived from mean grey-scale profiles of fundus autofluorescence images correlated closely with that obtained psychophysically (r=0.96). Autofluorescence imaging provides a fast non-invasive method for assessing MP in vivo.

KW - Age-related macular degeneration

KW - Autofluorescence

KW - Imaging

KW - Macular pigment

KW - Motion photometry

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JO - Vision Research

JF - Vision Research

SN - 0042-6989

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ER -

Macular pigment density and distribution: Comparison of fundus autofluorescence with minimum motion photometry

Abstract

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Keywords

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