Magnetic barcode nanowires for osteosarcoma cell control, detection and separation

Anirudh Sharma, Yuechen Zhu, Shengshee Thor, Fang Zhou, Bethanie Stadler, Allison Hubel

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Multilayered gold/nickel 'barcode' nanowires were grown using electrodeposition for multiplexed detection in biomolecular assays. Non-specific uptake of barcoded nanowires by osteosarcoma cells (OSCA-8) was observed by scanning and transmission electron microscopy images. Barcode-tagged cells were manipulated with an external magnetic field and were readily separated from untagged cells. Separation efficiency increased from a maximum of 30.14% to a maximum of 47.9% as clustering was reduced. Cells exposed to nanowires (both those that incorporated wires and those that did not) appeared to be viable suggesting that the nanowires are not toxic.

Original languageEnglish (US)
Article number6392423
Pages (from-to)453-456
Number of pages4
JournalIEEE Transactions on Magnetics
Volume49
Issue number1
DOIs
StatePublished - Jan 4 2013

Keywords

  • Cell manipulation
  • cellular uptake
  • magnetic carriers
  • magnetic separation
  • nanowires

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