Magnetic nanoparticle-based hyperthermia for head & neck cancer in mouse models

Qun Zhao; Luning Wang; Rui Cheng; Leidong Mao; Robert D. Arnold; Elizabeth W. Howerth; Zhuo G. Chen; Simon Platt

doi:10.7150/thno.3854

Magnetic nanoparticle-based hyperthermia for head & neck cancer in mouse models

Qun Zhao, Luning Wang, Rui Cheng, Leidong Mao, Robert D. Arnold, Elizabeth W. Howerth, Zhuo G. Chen, Simon Platt

Research output: Contribution to journal › Article › peer-review

159 Scopus citations

Abstract

In this study, magnetic iron oxide nanoparticle induced hyperthermia is applied for treatment of head and neck cancer using a mouse xenograft model of human head and neck cancer (Tu212 cell line). A hyperthermia system for heating iron oxide nanoparticles was developed by using alternating magnetic fields. Both theoretical simulation and experimental studies were performed to verify the thermotherapy effect. Experimental results showed that the temperature of the tumor center has dramatically elevated from around the room temperature to about 40°C within the first 5-10 minutes. Pathological studies demonstrate epithelial tumor cell destruction associated with the hyperthermia treatment.

Original language	English (US)
Pages (from-to)	113-121
Number of pages	9
Journal	Theranostics
Volume	2
Issue number	1
DOIs	https://doi.org/10.7150/thno.3854
State	Published - 2012
Externally published	Yes

Keywords

Head and neck cancer
Hyperthermia
Magnetic nanoparticles
Mouse

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.7150/thno.3854

OpenUrl availability

Full text

Cite this

@article{f4af9e45f7c6494f9ed51cd1247718f2,

title = "Magnetic nanoparticle-based hyperthermia for head & neck cancer in mouse models",

abstract = "In this study, magnetic iron oxide nanoparticle induced hyperthermia is applied for treatment of head and neck cancer using a mouse xenograft model of human head and neck cancer (Tu212 cell line). A hyperthermia system for heating iron oxide nanoparticles was developed by using alternating magnetic fields. Both theoretical simulation and experimental studies were performed to verify the thermotherapy effect. Experimental results showed that the temperature of the tumor center has dramatically elevated from around the room temperature to about 40°C within the first 5-10 minutes. Pathological studies demonstrate epithelial tumor cell destruction associated with the hyperthermia treatment.",

keywords = "Head and neck cancer, Hyperthermia, Magnetic nanoparticles, Mouse",

author = "Qun Zhao and Luning Wang and Rui Cheng and Leidong Mao and Arnold, {Robert D.} and Howerth, {Elizabeth W.} and Chen, {Zhuo G.} and Simon Platt",

year = "2012",

doi = "10.7150/thno.3854",

language = "English (US)",

volume = "2",

pages = "113--121",

journal = "Theranostics",

issn = "1838-7640",

publisher = "Ivyspring International Publisher",

number = "1",

}

TY - JOUR

T1 - Magnetic nanoparticle-based hyperthermia for head & neck cancer in mouse models

AU - Zhao, Qun

AU - Wang, Luning

AU - Cheng, Rui

AU - Mao, Leidong

AU - Arnold, Robert D.

AU - Howerth, Elizabeth W.

AU - Chen, Zhuo G.

AU - Platt, Simon

PY - 2012

Y1 - 2012

N2 - In this study, magnetic iron oxide nanoparticle induced hyperthermia is applied for treatment of head and neck cancer using a mouse xenograft model of human head and neck cancer (Tu212 cell line). A hyperthermia system for heating iron oxide nanoparticles was developed by using alternating magnetic fields. Both theoretical simulation and experimental studies were performed to verify the thermotherapy effect. Experimental results showed that the temperature of the tumor center has dramatically elevated from around the room temperature to about 40°C within the first 5-10 minutes. Pathological studies demonstrate epithelial tumor cell destruction associated with the hyperthermia treatment.

AB - In this study, magnetic iron oxide nanoparticle induced hyperthermia is applied for treatment of head and neck cancer using a mouse xenograft model of human head and neck cancer (Tu212 cell line). A hyperthermia system for heating iron oxide nanoparticles was developed by using alternating magnetic fields. Both theoretical simulation and experimental studies were performed to verify the thermotherapy effect. Experimental results showed that the temperature of the tumor center has dramatically elevated from around the room temperature to about 40°C within the first 5-10 minutes. Pathological studies demonstrate epithelial tumor cell destruction associated with the hyperthermia treatment.

KW - Head and neck cancer

KW - Hyperthermia

KW - Magnetic nanoparticles

KW - Mouse

UR - http://www.scopus.com/inward/record.url?scp=84863961365&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863961365&partnerID=8YFLogxK

U2 - 10.7150/thno.3854

DO - 10.7150/thno.3854

M3 - Article

C2 - 22287991

AN - SCOPUS:84863961365

SN - 1838-7640

VL - 2

SP - 113

EP - 121

JO - Theranostics

JF - Theranostics

IS - 1

ER -

Magnetic nanoparticle-based hyperthermia for head & neck cancer in mouse models

Abstract

Keywords

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this