Magneto acoustic tomography with short pulsed magnetic field for in-vivo imaging of magnetic iron oxide nanoparticles

Leo Mariappan, Qi Shao, Chunlan Jiang, Kai Yu, Shai Ashkenazi, John C Bischof, Bin He

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Nanoparticles are widely used as contrast and therapeutic agents. As such, imaging modalities that can accurately estimate their distribution in-vivo are actively sought. We present here our method Magneto Acoustic Tomography (MAT), which uses magnetomotive force due to a short pulsed magnetic field to induce ultrasound in the magnetic nanoparticle labeled tissue and estimates an image of the distribution of the nanoparticles in-vivo with ultrasound imaging resolution. In this study, we image the distribution of superparamagnetic iron oxide nanoparticles (IONP) using MAT method. In-vivo imaging was performed on live, nude mice with IONP injected into LNCaP tumors grown subcutaneously within the hind limb of the mice. Our experimental results indicate that the MAT method is capable of imaging the distribution of IONPs in-vivo. Therefore, MAT could become an imaging modality for high resolution reconstruction of MNP distribution in the body.

Original languageEnglish (US)
Pages (from-to)689-699
Number of pages11
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume12
Issue number3
DOIs
StatePublished - Apr 1 2016

Bibliographical note

Funding Information:
Funding: This work was supported in part by NIH EB014353 , EB017069 , EB006433 , and IEM Cancer Animal Core Lab .

Funding Information:
The authors would like to thank Dr. Michael Ethridge for useful discussions with magnetic nanoparticles. Also, they would like to thank Katie R. Hurley (Department of Chemistry, University of Minnesota) for TEM preparation, imaging and measurements of the radii of EMG-308.

Publisher Copyright:
© 2015 Elsevier Inc.

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

Keywords

  • In-vivo
  • Magnetic nano particle
  • Magneto acoustic tomography
  • Magneto motive force
  • Ultrasound

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