Malignancy in dermatomyositis: A retrospective study of 201 patients seen at the University of Pennsylvania

Kimberly Bowerman, David R. Pearson, Joyce Okawa, Victoria P. Werth

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: There is an increased incidence of malignancy in patients with dermatomyositis. It is unknown if the risk differs between the subtypes of dermatomyositis. Objective: To (1) compare the prevalence of malignancy-associated dermatomyositis between patients with classic and clinically amyopathic disease and (2) determine factors associated with an increased risk of malignancy-associated disease. Methods: Retrospective cohort study of 201 patients with adult-onset dermatomyositis prospectively enrolled in a longitudinal dermatomyositis database between July 2008 and April 2018 at an outpatient dermatology urban tertiary referral center. The main outcome measure was a diagnosis of malignancy, excluding nonmelanoma skin cancer. Results: There were 201 patients with adult-onset dermatomyositis: 142 (71%) classic and 59 (29%) clinically amyopathic. Within 2 years of diagnosis, the prevalences of malignancy-associated classic and clinically amyopathic dermatomyositis were 9.9% and 1.7%, respectively. In this time period, patients who were older at dermatomyositis diagnosis (P = .01) and had the classic subtype (P = .04) were significantly more likely to have an underlying malignancy on multivariable regression analysis. Limitations: This was a retrospective study of prospectively collected data at a single tertiary referral center. Conclusion: Older age and classic dermatomyositis are independent risk factors for malignancy-associated dermatomyositis within 2 years of disease onset.

Original languageEnglish (US)
Pages (from-to)117-122
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume83
Issue number1
DOIs
StatePublished - Jul 2020
Externally publishedYes

Bibliographical note

Funding Information:
Funding sources: Supported by the US Department of Veterans Affairs (Veterans Health Administration, Office of Research and Development and Biomedical Laboratory Research and Development).

Funding Information:
Funding sources: Supported by the US Department of Veterans Affairs ( Veterans Health Administration , Office of Research and Development and Biomedical Laboratory Research and Development ).

Publisher Copyright:
© 2020

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

  • connective tissue disease
  • dermatomyositis
  • malignancy
  • medical dermatology
  • paraneoplastic

PubMed: MeSH publication types

  • Journal Article

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