Maltreatment timing, HPA axis functioning, multigenic risk, and depressive symptoms in African American youth: Differential associations without moderated mediation

Adrienne A. Vanzomeren, Jingchen Zhang, Sun Kyung Lee, Meredith Gunlicks-Stoessel, Timothy Piehler, Dante Cicchetti

Research output: Contribution to journalArticlepeer-review

Abstract

Utilizing a large (N = 739), ancestrally homogenous sample, the current study aimed to better understand biological risk processes involved in the development of depressive symptoms in maltreated, African American children age 8-12 years. Maltreatment was independently coded from Child Protective Services records and maternal report. Self-reported depressive symptoms were attained in the context of a week-long, summer research camp. DNA was acquired from buccal cell or saliva samples and genotyped for nine polymorphisms in four hypothalamic-pituitary-adrenal (HPA)-axis-related genes: FKBP5, NR3C1, NR3C2, and CRHR1. Salivary cortisol samples were collected each morning (9 a.m.) and late afternoon (4 p.m.) throughout the week to assess HPA functioning. Results revealed that experiences of maltreatment beginning prior to age 5 were most predictive of depressive symptoms, whereas maltreatment onset after age 5 was most predictive of HPA axis dysregulation (blunted daytime cortisol patterns). Multigenic risk did not relate to HPA functioning, nor did it moderate the relationship between maltreatment and HPA activity. There was no mediation of the relationship between maltreatment and depressive symptoms by HPA dysfunction. Results are interpreted through a developmental psychopathology lens, emphasizing the principle of equifinality while carefully appraising racial differences. Implications for future research, particularly the need for longitudinal studies, and important methodological considerations are discussed.

Original languageEnglish (US)
Pages (from-to)1838-1853
Number of pages16
JournalDevelopment and psychopathology
Volume32
Issue number5
DOIs
StatePublished - Dec 2020

Bibliographical note

Funding Information:
Acknowledgments. Funding by the National Institute on Drug Abuse (R01-DA17741), The National Institute of Mental Health (R01-MH83979), and the Spunk Fund, Inc (to DC), as well as the National Science Foundation Graduate Research Fellowship Program (to AVZ).

Publisher Copyright:
Copyright © 2020 The Author(s). Published by Cambridge University Press.

Keywords

  • African American youth
  • depression
  • HPA axis
  • maltreatment
  • multigenic risk

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

Fingerprint

Dive into the research topics of 'Maltreatment timing, HPA axis functioning, multigenic risk, and depressive symptoms in African American youth: Differential associations without moderated mediation'. Together they form a unique fingerprint.

Cite this