Management of acute hypertensive response in patients with intracerebral hemorrhage

Syeda L. Alqadri, Adnan I Qureshi

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Spontaneous intracerebral hemorrhage (ICH) is intra-parenchymal bleeding that may lead to localized hematoma formation. The hematoma can enlarge over a period of time, and directly contribute to neurological deterioration and death. Several studies have shown a relationship between acute hypertensive response and poor prognosis among patients with ICH; however, it is somewhat unclear whether hematomal expansion, is a cause or a result of elevated blood pressure (BP). Current AHA guidelines state MAP should be maintained <130 mmHg and systolic blood pressure (SBP) <180 mmHg. Two major clinical trials demonstrating tolerability and safety of aggressive BPmanagement to BP <140 mmHg in the acute phase of ICH were the ATACH (2004-2008) and INTERACT (2005-2007) trials. ATACH II and INTERACT 2 trials are currently being conducted to demonstrate the efficacy of SBP reduction as the next step to the ATACH and INTERACT pilot trials.

Original languageEnglish (US)
Pages (from-to)322-327
Number of pages6
JournalCurrent atherosclerosis reports
Volume14
Issue number4
DOIs
StatePublished - Aug 2012

Bibliographical note

Funding Information:
Disclosure Dr. Qureshi has received funding from National Institutes of Health R0-1-NS44976-01AZ (Medication provided by ESP PHARMA) and 1U01NS062091-01A2: American Heart Association established investigator award 0840053N, and Minnesota Medical Foundation, Minneapolis, Mn.

Keywords

  • ATACH
  • ATACH II
  • Acute hypertensive response
  • Antihypertensive treatment
  • Cerebral blood flow
  • Cerebral perfusion pressure
  • Hypertension
  • INTERACT
  • INTERACT 2
  • Intracerebral hemorrhage
  • Ischemic penumbra
  • Mean arterial pressure
  • Perihematoma

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