Abstract
The clinical management of women with epilepsy on antiepileptic drugs (AEDs) during pregnancy presents unique challenges. The goal of treatment is optimal seizure control with minimal in utero fetal exposure to AEDs in an effort to reduce the risk of structural and neurodevelopmental teratogenic effects. This paper reviews the following key issues pertaining to women with epilepsy during pregnancy: AED pharmacokinetics; clinical management of AEDs; seizure frequency; major congenital malformation; neurodevelopmental outcomes; perinatal complications; and breast feeding.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 118-129 |
| Number of pages | 12 |
| Journal | Therapeutic Advances in Neurological Disorders |
| Volume | 9 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 1 2016 |
Bibliographical note
Publisher Copyright:© The Author(s), 2015.
Keywords
- antiepileptic drugs
- breast feeding
- epilepsy
- neurocognitive development
- perinatal outcomes
- pregnancy
- seizures
- teratogenicity
