Management of epilepsy during pregnancy: An update

Sima I. Patel, Page B. Pennell

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

The clinical management of women with epilepsy on antiepileptic drugs (AEDs) during pregnancy presents unique challenges. The goal of treatment is optimal seizure control with minimal in utero fetal exposure to AEDs in an effort to reduce the risk of structural and neurodevelopmental teratogenic effects. This paper reviews the following key issues pertaining to women with epilepsy during pregnancy: AED pharmacokinetics; clinical management of AEDs; seizure frequency; major congenital malformation; neurodevelopmental outcomes; perinatal complications; and breast feeding.

Original languageEnglish (US)
Pages (from-to)118-129
Number of pages12
JournalTherapeutic Advances in Neurological Disorders
Volume9
Issue number2
DOIs
StatePublished - Mar 1 2016

Bibliographical note

Publisher Copyright:
© The Author(s), 2015.

Keywords

  • antiepileptic drugs
  • breast feeding
  • epilepsy
  • neurocognitive development
  • perinatal outcomes
  • pregnancy
  • seizures
  • teratogenicity

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