Many gene-regulatory proteins appear to have a similar α-helical fold that binds DNA and evolved from a common precursor

Douglas H. Ohlendorf, Wayne F. Anderson, Brian W. Matthews

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

Amino acid and DNA sequence comparisons suggest that many sequence-specific DNA-binding proteins have in common and homologous region of about 22 amino acids. This region corresponds to two consecutive α-helices that occur in bot Cro and cI repressor proteins of bacteriophage λ and in catabolite gene activator protein of Escherichia coli and are presumed to interact with DNA. The results obtained here suggest that this α-helical DNA-binding fold occurs in many proteins that regulate gene expression. It also appears that this DNA-binding unit evolved from a common evolutionary precursor.

Original languageEnglish (US)
Pages (from-to)109-114
Number of pages6
JournalJournal of Molecular Evolution
Volume19
Issue number2
DOIs
StatePublished - Mar 1983

Keywords

  • DNA-binding protein
  • Gene regulation
  • Relatedness of proteins
  • α-helix

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