Mapping brain circuits of reward and motivation: In the footsteps of Ann Kelley

Jocelyn M. Richard, Daniel C. Castro, Alexandra G. DiFeliceantonio, Mike J.F. Robinson, Kent C. Berridge

Research output: Contribution to journalReview articlepeer-review

102 Scopus citations

Abstract

Ann Kelley was a scientific pioneer in reward neuroscience. Her many notable discoveries included demonstrations of accumbens/striatal circuitry roles in eating behavior and in food reward, explorations of limbic interactions with hypothalamic regulatory circuits, and additional interactions of motivation circuits with learning functions. Ann Kelley's accomplishments inspired other researchers to follow in her footsteps, including our own laboratory group. Here we describe results from several lines of our research that sprang in part from earlier findings by Kelley and colleagues. We describe hedonic hotspots for generating intense pleasure 'liking', separate identities of 'wanting' versus 'liking' systems, a novel role for dorsal neostriatum in generating motivation to eat, a limbic keyboard mechanism in nucleus accumbens for generating intense desire versus intense dread, and dynamic limbic transformations of learned memories into motivation. We describe how origins for each of these themes can be traced to fundamental contributions by Ann Kelley.

Original languageEnglish (US)
Pages (from-to)1919-1931
Number of pages13
JournalNeuroscience and Biobehavioral Reviews
Volume37
Issue number9
DOIs
StatePublished - Nov 2013
Externally publishedYes

Bibliographical note

Funding Information:
Some of the results described here are from work supported by National Institutes of Health grants DA015188 and MH63649 (KCB), F31 MH090602 (JMR), T32 DC00011 (DCC) and T32 DA007267 (AGD).

Keywords

  • Dopamine
  • Eating
  • Fear
  • Incentive salience
  • Neostriatum
  • Nucleus accumbens
  • Opioid
  • Pleasure
  • Rat
  • Ventral pallidum

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