Massing in high shear wet granulation can simultaneously improve powder flow and deteriorate powder compaction: A double-edged sword

Limin Shi, Yushi Feng, Calvin Sun

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

The influence of massing during high shear wet granulation (HSWG) process on granule properties and performance was investigated using microcrystalline cellulose (MCC). Massing time varied from 0 to 40 min while other factors were fixed. Granule physical properties, including morphology, size, porosity, and specific surface area (SSA), were characterized. Changes in powder properties were profound in the first 10 min of massing but negligible beyond 10 min. With 10 min of massing, granule tabletability decreased by 75% while flowability increased by 75%. The significantly deteriorated tabletability and improved flowability resulted from dramatic changes in granule morphology, porosity, and SSA. The results confirm that massing time is a key process parameter in HSWG, and it must be carefully evaluated and controlled during process development, scale up, and manufacturing.

Original languageEnglish (US)
Pages (from-to)50-56
Number of pages7
JournalEuropean Journal of Pharmaceutical Sciences
Volume43
Issue number1-2
DOIs
StatePublished - May 18 2011

Keywords

  • Flowability
  • High shear wet granulation
  • Massing
  • Over-granulation
  • Tabletability

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