Mast cell-mediated mechanisms of nociception

Anupam Aich, Lawrence B. Afrin, Kalpna Gupta

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations

Abstract

Mast cells are tissue-resident immune cells that release immuno-modulators, chemo-attractants, vasoactive compounds, neuropeptides and growth factors in response to allergens and pathogens constituting a first line of host defense. The neuroimmune interface of immune cells modulating synaptic responses has been of increasing interest, and mast cells have been proposed as key players in orchestrating inflammation-associated pain pathobiology due to their proximity to both vasculature and nerve fibers. Molecular underpinnings of mast cell-mediated pain can be disease-specific. Understanding such mechanisms is critical for developing disease-specific targeted therapeutics to improve analgesic outcomes. We review molecular mechanisms that may contribute to nociception in a disease-specific manner.

Original languageEnglish (US)
Pages (from-to)29069-29092
Number of pages24
JournalInternational journal of molecular sciences
Volume16
Issue number12
DOIs
StatePublished - Dec 4 2015

Keywords

  • Cancer
  • Cytokines
  • Hyperalgesia
  • Inflammation
  • Mast cells
  • Migraine
  • Pain
  • Sickle cell disease
  • Substance P
  • Tryptase

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