Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1

Peter A. Nigrovic, Bryce A. Binstadt, Paul A. Monach, Alyssa Johnsen, Michael Gurish, Yoichiro Iwakura, Christophe Benoist, Diane Mathis, David M. Lee

Research output: Contribution to journalArticlepeer-review

134 Scopus citations

Abstract

Mast cells are immune sentinels that participate in the defense against bacteria and parasites. Resident within the joint, mast cells become activated in human rheumatoid arthritis and are implicated in the pathogenesis of experimental murine synovitis. However, their arthritogenic role remains undefined. Using a model of autoantibody-induced arthritis, we show that mast cells contribute to the initiation of inflammation within the joint by elaboration of IL-1. Mast cells become activated to produce this cytokine via the IgG immune complex receptor FcγRIII. Interestingly, mast cells become dispensable for the perpetuation of arthritis after delivery of IL-1, highlighting the contribution of this lineage to arthritis induction. These findings illuminate a mechanism by which mast cells can participate in the pathogenesis of autoimmune inflammatory arthritis and provide insights of potential relevance to human rheumatoid arthritis.

Original languageEnglish (US)
Pages (from-to)2325-2330
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume104
Issue number7
DOIs
StatePublished - Feb 13 2007

Keywords

  • Cytokine
  • Mouse model
  • Synovitis

Fingerprint

Dive into the research topics of 'Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1'. Together they form a unique fingerprint.

Cite this