MB-SWIFT functional MRI during deep brain stimulation in rats

Lauri J. Lehto, Djaudat Idiyatullin, Jinjin Zhang, Lynn Utecht, Gregor Adriany, Michael Garwood, Olli Gröhn, Shalom Michaeli, Silvia Mangia

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Recently introduced 3D radial MRI pulse sequence entitled Multi-Band SWeep Imaging with Fourier Transformation (MB-SWIFT) having virtually zero acquisition delay was used to obtain functional MRI (fMRI) contrast in rat's brain at 9.4 T during deep brain stimulation (DBS). The results demonstrate that MB-SWIFT allows functional images free of susceptibility artifacts, and provides an excellent fMRI activation contrast in the brain. Flip angle dependence of the MB-SWIFT fMRI signal and elimination of the fMRI contrast while using saturation bands, indicate a blood flow origin of the observed fMRI contrast. MB-SWIFT fMRI modality permits activation studies in the close proximity to an implanted lead, which is not possible to achieve with conventionally used gradient echo and spin echo - echo planar imaging fMRI techniques. We conclude that MB-SWIFT fMRI is a powerful imaging modality for investigations of functional responses during DBS.

Original languageEnglish (US)
Pages (from-to)443-448
Number of pages6
JournalNeuroImage
Volume159
DOIs
StatePublished - Oct 1 2017

Bibliographical note

Funding Information:
This work was supported by: the National Institutes of Health (P41 EB015894, P30 NS076408); EU H2020 RISE MICROBRADAM, Professor Pool; WM KECK Foundation; MnDRIVE and The Emil Aaltonen Foundation post-doctoral fellowships to LJL. The authors are grateful to Prof. Kamil Ugurbil for stimulating discussions and comments on the manuscript.

Publisher Copyright:
© 2017 The Authors

Keywords

  • Blood flow
  • Deep brain stimulation
  • Multi-band SWIFT
  • Zero-TE fMRI
  • fMRI

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