TY - JOUR
T1 - MC1R variants and cutaneous melanoma risk according to histological type, body site, and Breslow thickness
T2 - a pooled analysis from the M-SKIP project
AU - Caini, Saverio
AU - Gandini, Sara
AU - Botta, Francesca
AU - Tagliabue, Elena
AU - Raimondi, Sara
AU - Nagore, Eduardo
AU - Zanna, Ines
AU - Maisonneuve, Patrick
AU - Newton-Bishop, Julia
AU - Polsky, David
AU - Lazovich, De Ann
AU - Kumar, Rajiv
AU - Kanetsky, Peter A.
AU - Hoiom, Veronica
AU - Ghiorzo, Paola
AU - Landi, Maria Teresa
AU - Ribas, Gloria
AU - Menin, Chiara
AU - Stratigos, Alexander J.
AU - Palmieri, Giuseppe
AU - Guida, Gabriella
AU - García-Borrón, Jose Carlos
AU - Nan, Hongmei
AU - Little, Julian
AU - Sera, Francesco
AU - Puig, Susana
AU - Fargnoli, Maria Concetta
N1 - Publisher Copyright:
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Little is known on whether melanocortin 1 receptor (MC1R) associated cutaneous melanoma (CM) risk varies depending on histological subtype and body site, and whether tumour thickness at diagnosis (the most important prognostic factor for CM patients) differs between MC1R variant carriers and wild-type individuals. We studied the association between MC1R variants and CM risk by histological subtype, body site, and Breslow thickness, using the database of the M-SKIP project. We pooled individual data from 15 case-control studies conducted during 2005-2015 in Europe and the USA. Study-specific, multi-adjusted odds ratios were pooled into summary odds ratios (SOR) and 95% confidence intervals (CI) using random-effects models. Six thousand eight hundred ninety-one CM cases and 5555 controls were included. CM risk was increased among MC1R variant carriers vs. wild-type individuals. The increase in risk was comparable across histological subtypes (SOR for any variant vs. wild-type ranged between 1.57 and 1.70, always statistical significant) except acral lentiginous melanoma (ALM), for which no association emerged; and slightly greater on chronically (1.74, 95% CI 1.47-2.07) than intermittently (1.55, 95% CI 1.34-1.78) sun-exposed skin. CM risk was greater for those carrying 'R' vs. 'r' variants; correlated with the number of variants; and was more evident among individuals not showing the red hair colour phenotype. Breslow thickness was not associated with MC1R status. MC1R variants were associated with an increased risk of CM of any histological subtype (except ALM) and occurring on both chronically and intermittently sun-exposed skin.
AB - Little is known on whether melanocortin 1 receptor (MC1R) associated cutaneous melanoma (CM) risk varies depending on histological subtype and body site, and whether tumour thickness at diagnosis (the most important prognostic factor for CM patients) differs between MC1R variant carriers and wild-type individuals. We studied the association between MC1R variants and CM risk by histological subtype, body site, and Breslow thickness, using the database of the M-SKIP project. We pooled individual data from 15 case-control studies conducted during 2005-2015 in Europe and the USA. Study-specific, multi-adjusted odds ratios were pooled into summary odds ratios (SOR) and 95% confidence intervals (CI) using random-effects models. Six thousand eight hundred ninety-one CM cases and 5555 controls were included. CM risk was increased among MC1R variant carriers vs. wild-type individuals. The increase in risk was comparable across histological subtypes (SOR for any variant vs. wild-type ranged between 1.57 and 1.70, always statistical significant) except acral lentiginous melanoma (ALM), for which no association emerged; and slightly greater on chronically (1.74, 95% CI 1.47-2.07) than intermittently (1.55, 95% CI 1.34-1.78) sun-exposed skin. CM risk was greater for those carrying 'R' vs. 'r' variants; correlated with the number of variants; and was more evident among individuals not showing the red hair colour phenotype. Breslow thickness was not associated with MC1R status. MC1R variants were associated with an increased risk of CM of any histological subtype (except ALM) and occurring on both chronically and intermittently sun-exposed skin.
KW - Breslow thickness
KW - body site
KW - cutaneous melanoma
KW - histological subtype
KW - melanocortin 1 receptor
KW - pooled analysis
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UR - http://www.scopus.com/inward/citedby.url?scp=85090754275&partnerID=8YFLogxK
U2 - 10.1097/CMR.0000000000000668
DO - 10.1097/CMR.0000000000000668
M3 - Article
C2 - 32898390
AN - SCOPUS:85090754275
SN - 0960-8931
VL - 30
SP - 500
EP - 510
JO - Melanoma research
JF - Melanoma research
IS - 5
ER -