MCM10: One tool for all-Integrity, maintenance and damage control

Yee Mon Thu; Anja Katrin Bielinsky

doi:10.1016/j.semcdb.2014.03.017

MCM10: One tool for all-Integrity, maintenance and damage control

Yee Mon Thu, Anja Katrin Bielinsky

Molecular Biology (TMED)

Research output: Contribution to journal › Review article › peer-review

45 Scopus citations

Abstract

Minichromsome maintenance protein 10 (Mcm10) is an essential replication factor that is required for the activation of the Cdc45:Mcm2-7:GINS helicase. Mcm10's ability to bind both ds and ssDNA appears vital for this function. In addition, Mcm10 interacts with multiple players at the replication fork, including DNA polymerase-α and proliferating cell nuclear antigen with which it cooperates during DNA elongation. Mcm10 lacks enzymatic function, but instead provides the replication apparatus with an oligomeric scaffold that likely acts in the coordination of DNA unwinding and DNA synthesis. Not surprisingly, loss of Mcm10 engages checkpoint, DNA repair and SUMO-dependent rescue pathways that collectively counteract replication stress and chromosome breakage. Here, we review Mcm10's structure and function and explain how it contributes to the maintenance of genome integrity.

Original language	English (US)
Pages (from-to)	121-130
Number of pages	10
Journal	Seminars in Cell and Developmental Biology
Volume	30
DOIs	https://doi.org/10.1016/j.semcdb.2014.03.017
State	Published - Jun 2014

Bibliographical note

Funding Information:
The authors wish to acknowledge funding from the NIH ( GM074917 ) to A-K.B. and thank Drs. Brandt Eichman and Nadine Shaban for advice regarding the crystal structures.

Keywords

Cancer mutations
DNA replication
Genome integrity
Mcm10
OB-fold
STUbL

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "MCM10: One tool for all-Integrity, maintenance and damage control",

abstract = "Minichromsome maintenance protein 10 (Mcm10) is an essential replication factor that is required for the activation of the Cdc45:Mcm2-7:GINS helicase. Mcm10's ability to bind both ds and ssDNA appears vital for this function. In addition, Mcm10 interacts with multiple players at the replication fork, including DNA polymerase-α and proliferating cell nuclear antigen with which it cooperates during DNA elongation. Mcm10 lacks enzymatic function, but instead provides the replication apparatus with an oligomeric scaffold that likely acts in the coordination of DNA unwinding and DNA synthesis. Not surprisingly, loss of Mcm10 engages checkpoint, DNA repair and SUMO-dependent rescue pathways that collectively counteract replication stress and chromosome breakage. Here, we review Mcm10's structure and function and explain how it contributes to the maintenance of genome integrity.",

keywords = "Cancer mutations, DNA replication, Genome integrity, Mcm10, OB-fold, STUbL",

author = "Thu, {Yee Mon} and Bielinsky, {Anja Katrin}",

note = "Funding Information: The authors wish to acknowledge funding from the NIH ( GM074917 ) to A-K.B. and thank Drs. Brandt Eichman and Nadine Shaban for advice regarding the crystal structures.",

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AU - Bielinsky, Anja Katrin

N1 - Funding Information: The authors wish to acknowledge funding from the NIH ( GM074917 ) to A-K.B. and thank Drs. Brandt Eichman and Nadine Shaban for advice regarding the crystal structures.

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N2 - Minichromsome maintenance protein 10 (Mcm10) is an essential replication factor that is required for the activation of the Cdc45:Mcm2-7:GINS helicase. Mcm10's ability to bind both ds and ssDNA appears vital for this function. In addition, Mcm10 interacts with multiple players at the replication fork, including DNA polymerase-α and proliferating cell nuclear antigen with which it cooperates during DNA elongation. Mcm10 lacks enzymatic function, but instead provides the replication apparatus with an oligomeric scaffold that likely acts in the coordination of DNA unwinding and DNA synthesis. Not surprisingly, loss of Mcm10 engages checkpoint, DNA repair and SUMO-dependent rescue pathways that collectively counteract replication stress and chromosome breakage. Here, we review Mcm10's structure and function and explain how it contributes to the maintenance of genome integrity.

AB - Minichromsome maintenance protein 10 (Mcm10) is an essential replication factor that is required for the activation of the Cdc45:Mcm2-7:GINS helicase. Mcm10's ability to bind both ds and ssDNA appears vital for this function. In addition, Mcm10 interacts with multiple players at the replication fork, including DNA polymerase-α and proliferating cell nuclear antigen with which it cooperates during DNA elongation. Mcm10 lacks enzymatic function, but instead provides the replication apparatus with an oligomeric scaffold that likely acts in the coordination of DNA unwinding and DNA synthesis. Not surprisingly, loss of Mcm10 engages checkpoint, DNA repair and SUMO-dependent rescue pathways that collectively counteract replication stress and chromosome breakage. Here, we review Mcm10's structure and function and explain how it contributes to the maintenance of genome integrity.

KW - Cancer mutations

KW - DNA replication

KW - Genome integrity

KW - Mcm10

KW - OB-fold

KW - STUbL

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MCM10: One tool for all-Integrity, maintenance and damage control

Abstract

Bibliographical note

Keywords

UN SDGs

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