Measured maternal prepregnancy anthropometry and newborn DNA methylation

Edwina H. Yeung, Weihua Guan, Sunni L. Mumford, Robert M. Silver, Cuilin Zhang, Michael Y. Tsai, Enrique F. Schisterman

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Aim: We examined maternal prepregnancy anthropometry and cord blood DNA methylation. Methods: Associations between maternal measures (i.e., weight, height, waist circumference, hip circumference, skinfolds, leptin) and methylation β-values at each CpG (measured by the Infinium MethylationEPIC BeadChip) were estimated among 391 singletons. Results: Total of 18% of mothers were obese (body mass index ≥ 30) and 27% centrally obese (waist-to-hip ratio ≥ 0.85). One Bonferroni significant CpG with respect to obesity (cg02975187) and two with central obesity (cg12053563, cg12549355) were identified (p < 6 × 10 -8 ). A suggestive association (p < 10 -6 ) was observed at SFRS8 with increasing body mass index. SFRS8 was previously identified with propensity for weight gain in adults. Conclusion: While associations identified with multiple measures related to maternal adiposity suggest different pathways, methylation differences were small in magnitude.

Original languageEnglish (US)
Pages (from-to)187-198
Number of pages12
JournalEpigenomics
Volume11
Issue number2
DOIs
StatePublished - Feb 1 2019

Bibliographical note

Funding Information:
This work was supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NIH, Bethesda, MD, USA) under contract numbers HHSN267200603423, HHSN267200603424, HHSN267200603426 and HHSN275201300023I-HHSN2750008.

Keywords

  • DNA methylation
  • maternal obesity
  • newborn
  • pregnancy

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