Measured maternal prepregnancy anthropometry and newborn DNA methylation

Edwina H. Yeung; Weihua Guan; Sunni L. Mumford; Robert M. Silver; Cuilin Zhang; Michael Y. Tsai; Enrique F. Schisterman

doi:10.2217/epi-2018-0099

Measured maternal prepregnancy anthropometry and newborn DNA methylation

Edwina H. Yeung, Weihua Guan, Sunni L. Mumford, Robert M. Silver, Cuilin Zhang, Michael Y. Tsai, Enrique F. Schisterman

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Aim: We examined maternal prepregnancy anthropometry and cord blood DNA methylation. Methods: Associations between maternal measures (i.e., weight, height, waist circumference, hip circumference, skinfolds, leptin) and methylation β-values at each CpG (measured by the Infinium MethylationEPIC BeadChip) were estimated among 391 singletons. Results: Total of 18% of mothers were obese (body mass index ≥ 30) and 27% centrally obese (waist-to-hip ratio ≥ 0.85). One Bonferroni significant CpG with respect to obesity (cg02975187) and two with central obesity (cg12053563, cg12549355) were identified (p < 6 × 10 ^-8 ). A suggestive association (p < 10 ^-6 ) was observed at SFRS8 with increasing body mass index. SFRS8 was previously identified with propensity for weight gain in adults. Conclusion: While associations identified with multiple measures related to maternal adiposity suggest different pathways, methylation differences were small in magnitude.

Original language	English (US)
Pages (from-to)	187-198
Number of pages	12
Journal	Epigenomics
Volume	11
Issue number	2
DOIs	https://doi.org/10.2217/epi-2018-0099
State	Published - Feb 1 2019

Bibliographical note

Funding Information:
This work was supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NIH, Bethesda, MD, USA) under contract numbers HHSN267200603423, HHSN267200603424, HHSN267200603426 and HHSN275201300023I-HHSN2750008.

Publisher Copyright:
© 2019 Future Medicine Ltd.

Keywords

DNA methylation
maternal obesity
newborn
pregnancy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371845

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abstract = " Aim: We examined maternal prepregnancy anthropometry and cord blood DNA methylation. Methods: Associations between maternal measures (i.e., weight, height, waist circumference, hip circumference, skinfolds, leptin) and methylation β-values at each CpG (measured by the Infinium MethylationEPIC BeadChip) were estimated among 391 singletons. Results: Total of 18% of mothers were obese (body mass index ≥ 30) and 27% centrally obese (waist-to-hip ratio ≥ 0.85). One Bonferroni significant CpG with respect to obesity (cg02975187) and two with central obesity (cg12053563, cg12549355) were identified (p < 6 × 10 -8 ). A suggestive association (p < 10 -6 ) was observed at SFRS8 with increasing body mass index. SFRS8 was previously identified with propensity for weight gain in adults. Conclusion: While associations identified with multiple measures related to maternal adiposity suggest different pathways, methylation differences were small in magnitude.",

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AU - Tsai, Michael Y.

AU - Schisterman, Enrique F.

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Measured maternal prepregnancy anthropometry and newborn DNA methylation

Abstract

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Keywords

UN SDGs

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