Measurement of refractive index variation of physiological analytes using differential phase OCT

Kirill V. Larin; Taner Akkin; Thomas E. Milner; D. P. Dave; Massoud Motamedi; Rinat O. Esenaliev

doi:10.1117/12.532004

Measurement of refractive index variation of physiological analytes using differential phase OCT

Kirill V. Larin, Taner Akkin, Thomas E. Milner, D. P. Dave, Massoud Motamedi, Rinat O. Esenaliev

Research output: Contribution to journal › Conference article › peer-review

Abstract

We report results of a study using differential phase optical coherence tomography (DP-OCT) for measurement of variation of refractive index (n) vs. analyte concentration (C) in translucent solutions and turbid tissue phantoms. Variation of refractive index with analyte concentration (dn/dC) in aqueous solutions of glucose, calcium chloride, magnesium chloride, sodium chloride, potassium chloride, potassium bicarbonate, urea, bovine serum albumin, and bovine globulin was measured. Obtained results demonstrated: (1) dn/dC for glucose is significantly greater than that of other analytes in the physiological range; and (2) high sensitivity of DP-OCT method for measurement of analyte concentration.

Original language	English (US)
Pages (from-to)	31-34
Number of pages	4
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	5325
DOIs	https://doi.org/10.1117/12.532004
State	Published - 2004
Externally published	Yes
Event	Optical Diagnostics and Sensing IV - San Jose, CA, United States Duration: Jan 27 2004 → Jan 27 2004

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title = "Measurement of refractive index variation of physiological analytes using differential phase OCT",

abstract = "We report results of a study using differential phase optical coherence tomography (DP-OCT) for measurement of variation of refractive index (n) vs. analyte concentration (C) in translucent solutions and turbid tissue phantoms. Variation of refractive index with analyte concentration (dn/dC) in aqueous solutions of glucose, calcium chloride, magnesium chloride, sodium chloride, potassium chloride, potassium bicarbonate, urea, bovine serum albumin, and bovine globulin was measured. Obtained results demonstrated: (1) dn/dC for glucose is significantly greater than that of other analytes in the physiological range; and (2) high sensitivity of DP-OCT method for measurement of analyte concentration.",

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AU - Larin, Kirill V.

AU - Akkin, Taner

AU - Milner, Thomas E.

AU - Dave, D. P.

AU - Motamedi, Massoud

AU - Esenaliev, Rinat O.

PY - 2004

Y1 - 2004

N2 - We report results of a study using differential phase optical coherence tomography (DP-OCT) for measurement of variation of refractive index (n) vs. analyte concentration (C) in translucent solutions and turbid tissue phantoms. Variation of refractive index with analyte concentration (dn/dC) in aqueous solutions of glucose, calcium chloride, magnesium chloride, sodium chloride, potassium chloride, potassium bicarbonate, urea, bovine serum albumin, and bovine globulin was measured. Obtained results demonstrated: (1) dn/dC for glucose is significantly greater than that of other analytes in the physiological range; and (2) high sensitivity of DP-OCT method for measurement of analyte concentration.

AB - We report results of a study using differential phase optical coherence tomography (DP-OCT) for measurement of variation of refractive index (n) vs. analyte concentration (C) in translucent solutions and turbid tissue phantoms. Variation of refractive index with analyte concentration (dn/dC) in aqueous solutions of glucose, calcium chloride, magnesium chloride, sodium chloride, potassium chloride, potassium bicarbonate, urea, bovine serum albumin, and bovine globulin was measured. Obtained results demonstrated: (1) dn/dC for glucose is significantly greater than that of other analytes in the physiological range; and (2) high sensitivity of DP-OCT method for measurement of analyte concentration.

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Measurement of refractive index variation of physiological analytes using differential phase OCT

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