We report results of a study using differential phase optical coherence tomography (DP-OCT) for measurement of variation of refractive index (n) vs. analyte concentration (C) in translucent solutions and turbid tissue phantoms. Variation of refractive index with analyte concentration (dn/dC) in aqueous solutions of glucose, calcium chloride, magnesium chloride, sodium chloride, potassium chloride, potassium bicarbonate, urea, bovine serum albumin, and bovine globulin was measured. Obtained results demonstrated: (1) dn/dC for glucose is significantly greater than that of other analytes in the physiological range; and (2) high sensitivity of DP-OCT method for measurement of analyte concentration.
|Original language||English (US)|
|Number of pages||4|
|Journal||Proceedings of SPIE - The International Society for Optical Engineering|
|State||Published - Nov 16 2004|
|Event||Optical Diagnostics and Sensing IV - San Jose, CA, United States|
Duration: Jan 27 2004 → Jan 27 2004