@inproceedings{2f8f13e3ce584cfd91d0eab1913d5c9b,
title = "Measuring a slight difference in stretch between GC and at rich regions within the human genome",
abstract = "We present a method for measuring the difference in stretch between GC and AT rich regions within genomic DNA from a human cell line NA 12878. Individual molecules of long DNA contain fluorescent labels at a 7 base recognition site from Nt.BspQI and are confined in an array of nanochannels allowing for the molecules to be aligned to the human reference. Data was collected on over 450,000 DNA molecules and once aligned, the fluorescent nick sites within individual molecules provided a precise ruler for measuring stretch based on the known GC content within a pair of nick sites.",
keywords = "DNA, GC content, Nanochannel, Stretch",
author = "Reifenberger, {Jeffrey G.} and Chuang, {Hui Min} and Dorfman, {Kevin D.} and Han Cao",
year = "2020",
month = jan,
day = "1",
language = "English (US)",
series = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017",
publisher = "Chemical and Biological Microsystems Society",
pages = "289--290",
booktitle = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017",
note = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 ; Conference date: 22-10-2017 Through 26-10-2017",
}