TY - JOUR
T1 - Measuring chemotherapy-induced peripheral neuropathy in children
T2 - Development of the Ped-mTNS and pilot study results
AU - Gilchrist, Laura S.
AU - Tanner, Lynn
AU - Hooke, Mary C.
PY - 2009
Y1 - 2009
N2 - The aim of this study was to develop and test the feasibility of a chemotherapy-induced peripheral neuropathy (CIPN) measurement, the ped-mTNS, for use in school-aged children. After adapting an established adult measure (modified-Total Neuropathy Scale), the ped-mTNS was administered one time to 20 children ages 5-18 who were undergoing, or had recently completed, chemotherapy. The ability to complete the measurements, to be understood by school-aged children and represent their symptoms, and the frequency of signs and symptoms was assessed. The ped-mTNS was successfully completed in all children in under 10 minutes. Three children reported symptoms not covered by test items. Sixty percent (12/20) reported sensory symptoms and 55% (11/20) reported motor symptoms. On clinical examination, impairments were found in pin sensibility (30%), vibration (50%), distal muscle strength (90%), and deep tendon reflexes (95%). The mean score was 6.1 ± 3.8 out of possible 24. The ped-mTNS is a feasible measure of CIPN and further research is warranted.
AB - The aim of this study was to develop and test the feasibility of a chemotherapy-induced peripheral neuropathy (CIPN) measurement, the ped-mTNS, for use in school-aged children. After adapting an established adult measure (modified-Total Neuropathy Scale), the ped-mTNS was administered one time to 20 children ages 5-18 who were undergoing, or had recently completed, chemotherapy. The ability to complete the measurements, to be understood by school-aged children and represent their symptoms, and the frequency of signs and symptoms was assessed. The ped-mTNS was successfully completed in all children in under 10 minutes. Three children reported symptoms not covered by test items. Sixty percent (12/20) reported sensory symptoms and 55% (11/20) reported motor symptoms. On clinical examination, impairments were found in pin sensibility (30%), vibration (50%), distal muscle strength (90%), and deep tendon reflexes (95%). The mean score was 6.1 ± 3.8 out of possible 24. The ped-mTNS is a feasible measure of CIPN and further research is warranted.
UR - http://www.scopus.com/inward/record.url?scp=77953368803&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953368803&partnerID=8YFLogxK
U2 - 10.1097/01893697-200927030-00002
DO - 10.1097/01893697-200927030-00002
M3 - Article
AN - SCOPUS:77953368803
SN - 2168-3808
VL - 27
SP - 7
EP - 15
JO - Rehabilitation Oncology
JF - Rehabilitation Oncology
IS - 3
ER -