TY - JOUR
T1 - Measuring salivary blood
T2 - A potential in vivo assay to quantify platelet transfusion efficacy
AU - Gniadek, Thomas J.
AU - Pulkrabek, Shelley
AU - Cohn, Claudia S.
PY - 2017/9
Y1 - 2017/9
N2 - Salivary blood is known to increase in patients with intraoral mucosal bleeding. Mucosal bleeding is a frequent sequelae of thrombocytopenia, which is typically managed with platelet transfusion. Within the past few years, multiple different types of platelet products have become available, each with potential differences in efficacy. Typically, platelet transfusion efficacy is demonstrated by the increase in platelet count after transfusion. However this approach is complicated by the fact that activated platelets tend to produce lower post-transfusion platelet counts, but may be more efficacious in a bleeding patient. Intraoral blood levels, measured by salivary transferrin, urine dipstick hemoglobin or another method, could be used as an in vivo assay to monitor a patient's response to platelet transfusion and compare different types of platelet products.
AB - Salivary blood is known to increase in patients with intraoral mucosal bleeding. Mucosal bleeding is a frequent sequelae of thrombocytopenia, which is typically managed with platelet transfusion. Within the past few years, multiple different types of platelet products have become available, each with potential differences in efficacy. Typically, platelet transfusion efficacy is demonstrated by the increase in platelet count after transfusion. However this approach is complicated by the fact that activated platelets tend to produce lower post-transfusion platelet counts, but may be more efficacious in a bleeding patient. Intraoral blood levels, measured by salivary transferrin, urine dipstick hemoglobin or another method, could be used as an in vivo assay to monitor a patient's response to platelet transfusion and compare different types of platelet products.
UR - http://www.scopus.com/inward/record.url?scp=85025169293&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85025169293&partnerID=8YFLogxK
U2 - 10.1016/j.mehy.2017.07.020
DO - 10.1016/j.mehy.2017.07.020
M3 - Article
C2 - 28915959
AN - SCOPUS:85025169293
SN - 0306-9877
VL - 107
SP - 36
EP - 38
JO - Medical Hypotheses
JF - Medical Hypotheses
ER -