Mechanical disruption of thrombus following intravenous tissue plasminogen activator for ischemic stroke: Clinical investigation study

Adnan I. Qureshi, Nazli Janjua, Jawad F. Kirmani, Pansy Harris-Lane, M. Fareed K Suri, Jingying Zhou, Afshin A. Divani

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Background and Purpose: We prospectively evaluated the safety of aggressive mechanical disruption of thrombus following full-dose intravenous (IV) recombinant tissue plasminogen activator (rt-PA) to treat ischemic stroke in 24 patients with an initial National Institutes of Health stroke scale (NIHSS) score of ≥10. Methods: Clinical evaluations were performed at presentation and 24 hours, 7 to 10 days, and 1 to 3 months (using modified Rankin scale) after treatment. These end points were compared to matched historical controls treated with IV rt-PA alone. Results: Of the 24 patients, mechanical disruption was undertaken in 17 patients with persistent angiographic occlusion using microcatheter exploration (n = 3), angioplasty (n = 5), snare maneuvers (n = 7), and combination of both (n = 2). Partial or complete recanalization was observed in 10 of the 17 patients. Neurological improvement at 24 hours (≥4 point reduction in NIHSS score) was observed in 11 of 17 patients. Comparisons with matched controls suggest potential equivalence for symptomatic ICH (0% vs 12%), asymptomatic ICH (18% vs 15%), and early neurological improvement (65% vs 53%). Conclusion: The study shows that aggressive mechanical thrombus disruption in large artery occlusion in the setting of acute ischemic stroke is safe with acceptable rates of ICH and promotes angiographic recanalization.

Original languageEnglish (US)
Pages (from-to)124-130
Number of pages7
JournalJournal of Neuroimaging
Volume17
Issue number2
DOIs
StatePublished - Apr 1 2007

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