Mechanical properties and cytocompatibility of biomimetic hydroxyapatite-gelatin nanocomposites

Ching Chang Ko, Michelle Oyen, Alison M. Fallgatter, Jin Hong Kim, Jim Fricton, Wei Shou Hu

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

A hydroxyapatite-gelatin nanocomposite system has been developed to resemble the composition and ultrastructure of natural bone for the application of tissue engineering. In the current study, variations in composition - content of gelatin and glutaraldehyde crosslinker - were examined in the context of mechanical properties and material biocompatibility. It was found that increasing the gelatin concentration resulted in a decreased hydroxyapatite crystal length and was associated with a slight increase in elastic modulus. Increases in gelatin and glutaraldehyde content were associated with increased material fracture toughness. Cellular biocompatibility tests, including cellular attachment and proliferation assays, were also used to assist in the process of optimizing gelatin and glutaraldohyde content. Optimized biomimetic nanocomposite materials for in vivo applications will likely be a compromise between the improved mechanical properties and decreased cytocompatibility associated with increased glutaraldehyde contents.

Original languageEnglish (US)
Pages (from-to)3090-3098
Number of pages9
JournalJournal of Materials Research
Volume21
Issue number12
DOIs
StatePublished - Dec 2006

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