Mechanism of inhibition of HIV-1 reverse transcriptase by the novel broad-range DNA polymerase inhibitor N-{2-[4-(Aminosulfonyl)phenyl]ethyl}-2-(2- thienyl)acetamide

Medicine & Life Sciences

• Nucleic Acid Synthesis Inhibitors 76%
• Human immunodeficiency virus 1 reverse transcriptase 75%
• RNA-Directed DNA Polymerase 64%
• DNA-Directed DNA Polymerase 49%
• Reverse Transcriptase Inhibitors 26%
• Human immunodeficiency virus 2 reverse transcriptase 20%
• thymidine 5'-triphosphate 16%
• Ribonuclease H 15%
• Anti-HIV Agents 15%
• Surface Plasmon Resonance 13%
• Polymerization 11%
• Lead 10%
• Inhibitory Concentration 50 9%
• Acquired Immunodeficiency Syndrome 9%
• Gels 8%
• N-(2-(4-(aminosulfonyl)phenyl)ethyl)-2-(2-thienyl)acetamide 8%
• Kinetics 7%
• RNA 7%
• HIV 7%
• DNA 6%
• In Vitro Techniques 4%
• Pharmaceutical Preparations 4%

Chemical Compounds

• DNA Polymerase Inhibitor 100%
• Acetamide 59%
• Ethyl 39%
• Anti Human Immunodeficiency Virus Agent 19%
• dTTP 19%
• Nonnucleoside Reverse Transcriptase Inhibitor 19%
• Surface Plasmon Resonance 13%
• Gel 8%
• Polymerization Reaction 8%