TY - JOUR
T1 - Mechanisms for cachexia in heart failure
AU - Pureza, Vincent
AU - Florea, Viorel
PY - 2013/12
Y1 - 2013/12
N2 - The combination of profound muscle wasting and severe weight loss that occurs in heart failure is a complex phenomenon that involves the interplay of numerous factors. In this article, we describe processes that contribute to cachexia, as part of the clinical sequelae of heart failure, and their potential underlying mechanisms. While multiple mechanisms of cardiac cachexia have been described, we propose a multifactorial etiology for this condition that includes, but is not limited to, nutritional and gastrointestinal alterations, immunological and neurohormonal activation, and anabolic and catabolic imbalance.
AB - The combination of profound muscle wasting and severe weight loss that occurs in heart failure is a complex phenomenon that involves the interplay of numerous factors. In this article, we describe processes that contribute to cachexia, as part of the clinical sequelae of heart failure, and their potential underlying mechanisms. While multiple mechanisms of cardiac cachexia have been described, we propose a multifactorial etiology for this condition that includes, but is not limited to, nutritional and gastrointestinal alterations, immunological and neurohormonal activation, and anabolic and catabolic imbalance.
KW - Anabolic-catabolic imbalance
KW - Cachexia
KW - Cytokines
KW - Heart failure
KW - Immunological activation
KW - Neurohormonal activation
KW - Obesity paradox
KW - Tumor necrosis factor-alpha
UR - http://www.scopus.com/inward/record.url?scp=84888023297&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84888023297&partnerID=8YFLogxK
U2 - 10.1007/s11897-013-0153-9
DO - 10.1007/s11897-013-0153-9
M3 - Article
C2 - 23925442
AN - SCOPUS:84888023297
SN - 1546-9530
VL - 10
SP - 307
EP - 314
JO - Current Heart Failure Reports
JF - Current Heart Failure Reports
IS - 4
ER -