Mechanisms of adaptive immunity to porcine reproductive and respiratory syndrome virus

Michael C. Rahe, Michael P. Murtaugh

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

The adaptive immune response is necessary for the development of protective immunity against infectious diseases. Porcine reproductive and respiratory syndrome virus (PRRSV), a genetically heterogeneous and rapidly evolving RNA virus, is the most burdensome pathogen of swine health and wellbeing worldwide. Viral infection induces antigen-specific immunity that ultimately clears the infection. However, the resulting immune memory, induced by virulent or attenuated vaccine viruses, is inconsistently protective against diverse viral strains. The immunological mechanisms by which primary and memory protection are generated and used are not well understood. Here, we summarize current knowledge regarding cellular and humoral components of the adaptive immune response to PRRSV infection that mediate primary and memory immune protection against viruses.

Original languageEnglish (US)
Article number148
JournalViruses
Volume9
Issue number6
DOIs
StatePublished - Jun 13 2017

Bibliographical note

Funding Information:
The authors were supported in part by Agriculture and Food Research Initiative Competitive Grant No. 2016-67015-24928 from the USDA National Institute of Food and Agriculture and NIH award T32 OD010993 for support of M.C.R.

Publisher Copyright:
© 2017 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Adaptive immune response
  • B cell
  • Memory
  • NK cell
  • Neutralizing antibody
  • PRRSV
  • Porcine
  • T cell

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