Melamine and Cyanuric Acid-Induced Crystalluria, Uroliths, and Nephrotoxicity in Dogs and Cats

Carl A. Osborne, Jody P. Lulich, Lisa K. Ulrich, Lori A. Koehler, Hasan Albasan, Linda Sauer, Gernot Schubert

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations

Abstract

This article discusses the 2007 recall of canned pet food because of concerns about adverse effects on kidney function of cats and dogs. The discovery of melamine and cyanuric acid in the foods is detailed. Case studies, including clinical, pathology, histology, and toxicology findings, are presented. An attempt is being made to identify the minerals in the uroliths and kidney tissues of affected animals.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalVeterinary Clinics of North America - Small Animal Practice
Volume39
Issue number1
DOIs
StatePublished - Jan 2009

Bibliographical note

Funding Information:
In addition to the educational gift provided by Hill's Pet Nutrition, parts of this work were performed in the Institute of Technology Characterization Facility, University of Minnesota, which receives partial support from the National Science Foundation through the National Nanotechnology Infrastructure Network program.

Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.

Keywords

  • Crystalluria
  • Cyanuric acid
  • Melamine
  • Nephrotoxicity
  • Uric acid monohydrate
  • Uroliths
  • Wheat gluten

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