Melamine and Cyanuric Acid-Induced Crystalluria, Uroliths, and Nephrotoxicity in Dogs and Cats

Carl A. Osborne; Jody P. Lulich; Lisa K. Ulrich; Lori A. Koehler; Hasan Albasan; Linda Sauer; Gernot Schubert

doi:10.1016/j.cvsm.2008.09.010

Melamine and Cyanuric Acid-Induced Crystalluria, Uroliths, and Nephrotoxicity in Dogs and Cats

Carl A. Osborne, Jody P. Lulich, Lisa K. Ulrich, Lori A. Koehler, Hasan Albasan, Linda Sauer, Gernot Schubert

Veterinary Clinical Sciences

Research output: Contribution to journal › Review article › peer-review

56 Scopus citations

Abstract

This article discusses the 2007 recall of canned pet food because of concerns about adverse effects on kidney function of cats and dogs. The discovery of melamine and cyanuric acid in the foods is detailed. Case studies, including clinical, pathology, histology, and toxicology findings, are presented. An attempt is being made to identify the minerals in the uroliths and kidney tissues of affected animals.

Original language	English (US)
Pages (from-to)	1-14
Number of pages	14
Journal	Veterinary Clinics of North America - Small Animal Practice
Volume	39
Issue number	1
DOIs	https://doi.org/10.1016/j.cvsm.2008.09.010
State	Published - Jan 2009

Bibliographical note

Funding Information:
In addition to the educational gift provided by Hill's Pet Nutrition, parts of this work were performed in the Institute of Technology Characterization Facility, University of Minnesota, which receives partial support from the National Science Foundation through the National Nanotechnology Infrastructure Network program.

Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.

Keywords

Crystalluria
Cyanuric acid
Melamine
Nephrotoxicity
Uric acid monohydrate
Uroliths
Wheat gluten

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title = "Melamine and Cyanuric Acid-Induced Crystalluria, Uroliths, and Nephrotoxicity in Dogs and Cats",

abstract = "This article discusses the 2007 recall of canned pet food because of concerns about adverse effects on kidney function of cats and dogs. The discovery of melamine and cyanuric acid in the foods is detailed. Case studies, including clinical, pathology, histology, and toxicology findings, are presented. An attempt is being made to identify the minerals in the uroliths and kidney tissues of affected animals.",

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note = "Funding Information: In addition to the educational gift provided by Hill's Pet Nutrition, parts of this work were performed in the Institute of Technology Characterization Facility, University of Minnesota, which receives partial support from the National Science Foundation through the National Nanotechnology Infrastructure Network program. Copyright: Copyright 2009 Elsevier B.V., All rights reserved.",

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AU - Koehler, Lori A.

AU - Albasan, Hasan

AU - Sauer, Linda

AU - Schubert, Gernot

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Melamine and Cyanuric Acid-Induced Crystalluria, Uroliths, and Nephrotoxicity in Dogs and Cats

Abstract

Bibliographical note

Keywords

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