Merging the potential of microbial genetics with biological and chemical diversity: An even brighter future for marine natural product drug discovery

Christine Salomon, Nathan A. Magarvey, David H. Sherman

Research output: Contribution to journalReview articlepeer-review

119 Scopus citations

Abstract

Marine invertebrates and a growing number of marine bacteria are the sources of novel, bioactive secondary metabolites. Structurally, many of these compounds appear to be biosynthesized by polyketide synthases (PKS) and/or nonribosomal peptide synthetases (NRPS) that have also been found in terrestrial microbes. This review highlights scientific advances from 1999-2003 in the emerging field of molecular genetics of polyketide and nonribosomal peptide natural products isolated from marine organisms. The implications of this research towards the development of marine secondary metabolites as a sustainable source of new drugs are discussed.

Original languageEnglish (US)
Pages (from-to)105-121
Number of pages17
JournalNatural Product Reports
Volume21
Issue number1
DOIs
StatePublished - Feb 2004

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