Meta-analysis of Bioabsorbable Staple Line Reinforcement and Risk of Fistula Following Pancreatic Resection

Eric H. Jensen, Pamela R. Portschy, Jessica Chowaniec, Ming Teng

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Background: Stapled pancreatic transection is widely used although pancreatic fistula remains a common post-surgical complication. Methods: We performed a meta-analysis of existing data regarding pancreatic fistula following stapled pancreatic transection, comparing bare metal staples to reinforced staple loads. Results: We identified ten manuscripts between 2007 and 2009 reporting outcomes following stapled division of the pancreas (five retrospective reviews, five prospective case series). A total of 483 stapled pancreatic resections are included in this meta-analysis. Of these, 234(48 %) were reinforced (REINF) and 249 (52 %) were bare staples (STPL). Out of 483 cases, there were a total of 100 documented pancreatic leaks (21 %). Sixty-one leaks were reported out of 249 STPL divisions (24 %), while 39 leaks were reported following REINF division (17 %). The overall relative risk of developing a pancreatic fistula following distal pancreatectomy was not significantly different comparing STPL to REINF when all studies were combined (RR 1.00, 95% CI 0.65-1.53). We further evaluated the data stratifying by study design (prospective or retrospective) and found that prospective studies reported a significantly higher risk of pancreatic fistula with STPL compared to REINF technique (RR 14.45, 95 % CI 3.15-66.21). Conclusion: Reinforced staples may be a preferred method of pancreatic stump closure following distal pancreatectomy.

Original languageEnglish (US)
Pages (from-to)267-272
Number of pages6
JournalJournal of Gastrointestinal Surgery
Issue number2
StatePublished - Feb 2013

Bibliographical note

Copyright 2021 Elsevier B.V., All rights reserved.


  • Pancreas
  • Pancreatic fistula
  • Staple line reinforcement


Dive into the research topics of 'Meta-analysis of Bioabsorbable Staple Line Reinforcement and Risk of Fistula Following Pancreatic Resection'. Together they form a unique fingerprint.

Cite this