Meta-Dimethoxy-Substituted Difluoroboron Dibenzoylmethane Poly(Lactic Acid) Nanoparticles for Luminescence Anisotropy

Meng Zhuang, Anna Perkins, Christopher A. DeRosa, Tristan Butler, James N. Demas, Cassandra L. Fraser

Research output: Contribution to journalArticlepeer-review

Abstract

Difluoroboron β-diketonates derivatives are dyes with tunable fluorescence and room temperature phosphorescence when embedded in a rigid matrix such as poly(lactic acid) (PLA). Both fluorescence and phosphorescence are present in solid-state PLA, enabling a variety of applications such as bio-imaging and oxygen sensing. Here, a meta-dimethoxy-substituted difluoroboron dibenzoylmethane [BF2dbm(m-OMe)2OH] is prepared, and two PLA polymers [BF2dbm(m-OMe)2PLA] with different dye loadings are produced. Optical properties are studied in solution, and the emissions are environment sensitive. This is supported by density functional theory (DFT) calculations where intramolecular charge transfer is present and related to solvatochromism. Nanoparticles are fabricated with solvents of varied polarities via nanoprecipitation. Dynamic light scattering indicates dimethylformamide generates the smallest nanoparticles and tetrahydrofuran the largest. Luminescence polarization establishes that the absorbing and emitting dipoles are single axis and collinear. Förster resonance energy transfer within the nanoparticles is important and depends strongly on dye loadings.

Original languageEnglish (US)
Article number1800240
JournalMacromolecular Chemistry and Physics
Volume219
Issue number22
DOIs
StatePublished - Nov 2018

Bibliographical note

Funding Information:
The authors thank the National Institute of Health (R01 CA167250) and the University of Virginia, Department of Chemistry for support for this research. The authors gratefully acknowledge Fang Wang for his help with solvatochromism and DFT calculations.

Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

  • difluoroboron β-diketonate
  • luminescence
  • polarization anisotropy
  • poly(lactic acid) nanoparticles
  • solvatochromism

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