Metabolic assessment prior to total pancreatectomy and islet autotransplant: Utility, limitations and potential

R. Lundberg, G. J. Beilman, Ty B Dunn, Timothy L Pruett, S. C. Chinnakotla, David M Radosevich, Paul Robertson, P. Ptacek, A. N. Balamurugan, J. J. Wilhelm, B. J. Hering, D. E.R. Sutherland, A. Moran, M. D. Bellin

Research output: Contribution to journalArticlepeer-review

Abstract

Islet autotransplant (IAT) may ameliorate postsurgical diabetes following total pancreatectomy (TP), but outcomes are dependent upon islet mass, which is unknown prior to pancreatectomy. We evaluated whether preoperative metabolic testing could predict islet isolation outcomes and thus improve assessment of TPIAT candidates. We examined the relationship between measures from frequent sample IV glucose tolerance tests (FSIVGTT) and mixed meal tolerance tests (MMTT) and islet mass in 60 adult patients, with multivariate logistic regression modeling to identify predictors of islet mass ≥2500 IEQ/kg. The acute C-peptide response to glucose (ACRglu) and disposition index from FSIVGTT correlated modestly with the islet equivalents per kilogram body weight (IEQ/kg). Fasting and MMTT glucose levels and HbA1c correlated inversely with IEQ/kg (r values -0.33 to -0.40, p ≤ 0.05). In multivariate logistic regression modeling, normal fasting glucose (<100 mg/dL) and stimulated C-peptide on MMTT ≥4 ng/mL were associated with greater odds of receiving an islet mass ≥2500 IEQ/kg (OR 0.93 for fasting glucose, CI 0.87-1.0; OR 7.9 for C-peptide, CI 1.75-35.6). In conclusion, parameters obtained from FSIVGTT correlate modestly with islet isolation outcomes. Stimulated C-peptide ≥4 ng/mL on MMTT conveyed eight times the odds of receiving ≥2500 IEQ/kg, a threshold associated with reasonable metabolic control postoperatively. In adult patients with chronic pancreatitis undergoing total pancreatectomy and islet autotransplant, the authors show that metabolic testing performed prior to transplant is modestly helpful in predicting which patients are likely to have at least a moderate islet mass isolated for transplant.

Original languageEnglish (US)
Pages (from-to)2664-2671
Number of pages8
JournalAmerican Journal of Transplantation
Volume13
Issue number10
DOIs
StatePublished - Oct 2013

Keywords

  • autoislet
  • chronic pancreatitis
  • Diabetes mellitus
  • islet transplant
  • pancreatitis
  • total pancreatectomy

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