Metabolism of O6-propyl and N6-propyl-carbovir in CEM cells

William B. Parker; Sue C. Shaddix; Lucy M. Rose; Phuong T. Pham; Mei Hua; Robert Vince

doi:10.1080/15257770008035025

Metabolism of O⁶-propyl and N⁶-propyl-carbovir in CEM cells

William B. Parker, Sue C. Shaddix, Lucy M. Rose, Phuong T. Pham, Mei Hua, Robert Vince

Center for Drug Design

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The metabolism of O⁶-propyl-carbovir and N₆-propyl-carbovir, two selective inhibitors of HIV replication, has been evaluated in CEM cells. Both compounds were phosphorylated in intact cells to carbovir-5'- triphosphate. The metabolism of these two agents was inhibited by deoxycoformycin and mycophenolic acid, but not erythro-9-(2-hydroxy-3- nonyl)adenine. No evidence of the 5'-triphosphate of either compound was detected in CEM cells.

Original language	English (US)
Pages (from-to)	795-804
Number of pages	10
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	19
Issue number	4
DOIs	https://doi.org/10.1080/15257770008035025
State	Published - 2000

Bibliographical note

Funding Information:
This work was supported by NIH grant numbers A1291 57 and

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title = "Metabolism of O6-propyl and N6-propyl-carbovir in CEM cells",

abstract = "The metabolism of O6-propyl-carbovir and N6-propyl-carbovir, two selective inhibitors of HIV replication, has been evaluated in CEM cells. Both compounds were phosphorylated in intact cells to carbovir-5'- triphosphate. The metabolism of these two agents was inhibited by deoxycoformycin and mycophenolic acid, but not erythro-9-(2-hydroxy-3- nonyl)adenine. No evidence of the 5'-triphosphate of either compound was detected in CEM cells.",

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AU - Shaddix, Sue C.

AU - Rose, Lucy M.

AU - Pham, Phuong T.

AU - Hua, Mei

AU - Vince, Robert

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AB - The metabolism of O6-propyl-carbovir and N6-propyl-carbovir, two selective inhibitors of HIV replication, has been evaluated in CEM cells. Both compounds were phosphorylated in intact cells to carbovir-5'- triphosphate. The metabolism of these two agents was inhibited by deoxycoformycin and mycophenolic acid, but not erythro-9-(2-hydroxy-3- nonyl)adenine. No evidence of the 5'-triphosphate of either compound was detected in CEM cells.

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