The metabolism of O6-propyl-carbovir and N6-propyl-carbovir, two selective inhibitors of HIV replication, has been evaluated in CEM cells. Both compounds were phosphorylated in intact cells to carbovir-5'- triphosphate. The metabolism of these two agents was inhibited by deoxycoformycin and mycophenolic acid, but not erythro-9-(2-hydroxy-3- nonyl)adenine. No evidence of the 5'-triphosphate of either compound was detected in CEM cells.
Bibliographical noteFunding Information:
This work was supported by NIH grant numbers A1291 57 and