TY - JOUR
T1 - Methadone-related delirium prevalence, causes, and outcomes
AU - Westermeyer, Joseph
AU - Thuras, Paul
AU - Yoon, Gihyun
AU - Kolla, Bhanu Prakash
AU - Batres-Y-Carr, Tegan
AU - Dimitropoulos, Erica
N1 - Publisher Copyright:
Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2019/5
Y1 - 2019/5
N2 - Goals consist of determining 5-year prevalence and recurrence of methadone-related delirium (MRD), along with causes, treatments, and outcomes. Sample comprised 81 patients in methadone maintenance treatment. Criteria for MRD encompassed delirium with high methadone serum levels plus alleviation of delirium upon lowering methadone serum levels. MRD occurred in 14 cases who had 25 episodes. MRD precipitants included physician prescribing (i.e., excessive methadone or medications slowing methadone metabolism), drug misuse, and renal-fluid alterations. Social affiliation (housing with family, intimate partner) reduced MRD; employment increased MRD. Recovery occurred in 23/25 episodes of MRD; two episodes progressed to dementia. Obtaining serum methadone levels fostered prompt recognition.
AB - Goals consist of determining 5-year prevalence and recurrence of methadone-related delirium (MRD), along with causes, treatments, and outcomes. Sample comprised 81 patients in methadone maintenance treatment. Criteria for MRD encompassed delirium with high methadone serum levels plus alleviation of delirium upon lowering methadone serum levels. MRD occurred in 14 cases who had 25 episodes. MRD precipitants included physician prescribing (i.e., excessive methadone or medications slowing methadone metabolism), drug misuse, and renal-fluid alterations. Social affiliation (housing with family, intimate partner) reduced MRD; employment increased MRD. Recovery occurred in 23/25 episodes of MRD; two episodes progressed to dementia. Obtaining serum methadone levels fostered prompt recognition.
KW - Delirium
KW - Maintenance
KW - Methadone
KW - Risk factors
KW - Treatment methods
KW - Treatment outcome
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U2 - 10.1097/NMD.0000000000000978
DO - 10.1097/NMD.0000000000000978
M3 - Article
C2 - 30958424
AN - SCOPUS:85064885492
SN - 0022-3018
VL - 207
SP - 371
EP - 377
JO - Journal of Nervous and Mental Disease
JF - Journal of Nervous and Mental Disease
IS - 5
ER -