TY - JOUR
T1 - Microalbuminuria in the US population
T2 - Third National Health and Nutrition Examination Survey
AU - Jones, Camille A.
AU - Francis, Mildred E.
AU - Eberhardt, Mark S.
AU - Chavers, Blanche
AU - Coresh, Josef
AU - Engelgau, Michael
AU - Kusek, John W.
AU - Byrd-Holt, Danita
AU - Venkat Narayan, K. M.
AU - Herman, William H.
AU - Jones, Camara P.
AU - Salive, Marcel
AU - Agodoa, Lawrence Y.
PY - 2002/3
Y1 - 2002/3
N2 - Microalbuminuria (MA) is associated with adverse health outcomes in diabetic and hypertensive adults. The prevalence and clinical significance of MA in nondiabetic populations is less clear. The purpose of this study was to generate national estimates of the prevalence of MA in the US population. Untimed urinary albumin concentrations (UACs) and creatinine concentrations were evaluated in a nationally representative sample of 22, 244 participants aged 6 years and older. Persons with hematuria and menstruating or pregnant women were excluded from analysis. The percent prevalence of clinical proteinuria (UAC ≥ 300 mg/L) was similar for males and females. However, the prevalence of MA (urinary albumin-creatinine ratio [ACR], 30 to 299 mg/g) was significantly lower in males (6.1%) compared with females (9.7%). MA prevalence was greater in children than young adults and increased continuously starting at 40 years of age. MA prevalence was greater in non-Hispanic blacks and Mexican Americans aged 40 to 79 years compared with similar-aged non-Hispanic whites. MA prevalence was 28.8% in persons with previously diagnosed diabetes, 16.0% in those with hypertension, and 5.1% in those without diabetes, hypertension, cardiovascular disease, or elevated serum creatinine levels. In adults aged 40+ years, after excluding persons with clinical proteinuria, albuminuria (defined as ACR ≥ 30 mg/g) was independently associated with older age, non-Hispanic black and Mexican American ethnicity, diabetes, hypertension, and elevated serum creatinine concentration. MA is common, even among persons without diabetes or hypertension. Age, sex, race/ethnicity, and concomitant disease contribute to the variability of MA prevalence estimates.
AB - Microalbuminuria (MA) is associated with adverse health outcomes in diabetic and hypertensive adults. The prevalence and clinical significance of MA in nondiabetic populations is less clear. The purpose of this study was to generate national estimates of the prevalence of MA in the US population. Untimed urinary albumin concentrations (UACs) and creatinine concentrations were evaluated in a nationally representative sample of 22, 244 participants aged 6 years and older. Persons with hematuria and menstruating or pregnant women were excluded from analysis. The percent prevalence of clinical proteinuria (UAC ≥ 300 mg/L) was similar for males and females. However, the prevalence of MA (urinary albumin-creatinine ratio [ACR], 30 to 299 mg/g) was significantly lower in males (6.1%) compared with females (9.7%). MA prevalence was greater in children than young adults and increased continuously starting at 40 years of age. MA prevalence was greater in non-Hispanic blacks and Mexican Americans aged 40 to 79 years compared with similar-aged non-Hispanic whites. MA prevalence was 28.8% in persons with previously diagnosed diabetes, 16.0% in those with hypertension, and 5.1% in those without diabetes, hypertension, cardiovascular disease, or elevated serum creatinine levels. In adults aged 40+ years, after excluding persons with clinical proteinuria, albuminuria (defined as ACR ≥ 30 mg/g) was independently associated with older age, non-Hispanic black and Mexican American ethnicity, diabetes, hypertension, and elevated serum creatinine concentration. MA is common, even among persons without diabetes or hypertension. Age, sex, race/ethnicity, and concomitant disease contribute to the variability of MA prevalence estimates.
KW - Albumin-creatinine ratio (ACR)
KW - Albuminuria
KW - Cross-sectional survey
KW - Diabetes
KW - Hypertension
KW - Microalbuminuria (MA)
KW - Population survey
KW - Prevalence
KW - Proteinuria
KW - Random untimed urine
KW - Third national health and nutrition examination survey (NHANES III)
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U2 - 10.1053/ajkd.2002.31388
DO - 10.1053/ajkd.2002.31388
M3 - Article
C2 - 11877563
AN - SCOPUS:0036189123
SN - 0272-6386
VL - 39
SP - 445
EP - 459
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 3
ER -