Microbiota transplant therapy and autism: lessons for the clinic

James B. Adams, Thomas J. Borody, Dae Wook Kang, Alexander Khoruts, Rosa Krajmalnik-Brown, Michael J. Sadowsky

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Introduction: The purpose of this review is to discuss Microbiota Transplant Therapy (MTT), a type of intensive intestinal microbiota transplantation (IMT), for people with autism spectrum disorders (ASD) and chronic gastrointestinal disorders (constipation and/or diarrhea). Areas covered: This paper briefly reviews IMT, gastrointestinal symptoms and gastrointestinal bacteria in children with ASD, and results and lessons learned from intensive MTT for autism. Expert opinion: An open-label study and a two-year follow-up suggest that MTT is relatively safe and effective in significantly reducing gastrointestinal disorders and autism symptoms, changing the gut microbiome structure, and increasing gut microbial diversity. Further research with larger, randomized, double-blind, placebo-controlled studies is warranted.

Original languageEnglish (US)
Pages (from-to)1033-1037
Number of pages5
JournalExpert Review of Gastroenterology and Hepatology
Issue number11
StatePublished - Nov 2 2019

Bibliographical note

Funding Information:
Several authors (JBA, D-WK, RKB, TB, AK, and MJS) have pending/approved patents related to the use of IMT and/or probiotics for various conditions including autism. MJS, AK, JBA, RKB, and D-WK have previously received research funding from Crestovo and Finch Therapeutics for IMT research, and JBA and RKB have current research projects with Finch Therapeutics. JBA and RKB were part-time consultants for Crestovo, and are currently part-time consultants for Finch Therapeutics. MJS was previously a part-time consultant for Finch Therapeutics.

Publisher Copyright:
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.


  • Autism
  • constipation
  • diarrhea
  • fecal microbiota transplant
  • gastrointestinal symptoms
  • intestinal microbiota transplant
  • microbiota transplant therapy
  • vancomycin

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